5-Nitro-2,3-dihydro-1-benzofuran

Base Information

• Chemical Name: 5-Nitro-2,3-dihydro-1-benzofuran
• CAS No.: 17403-47-3
• Molecular Formula: C8 H7 N O3
• Molecular Weight: 165.15
• Hs Code.: 2932999099
• Mol file: 17403-47-3.mol

Synonyms:5-nitro-2,3-dihydrobenzofuran;

Chemical Property of 5-Nitro-2,3-dihydro-1-benzofuran

Chemical Property:

• Boiling Point: 292.3±29.0 °C(Predicted)
• PSA: 55.05000
• Density: 1.360±0.06 g/cm3(Predicted)
• LogP: 2.05290
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-Nitro-2,3-dihydro-1-benzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Nitro-2,3-dihydro-1-benzofuran

There total 2 articles about 5-Nitro-2,3-dihydro-1-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2.3-dihydrobenzofuran (496-16-2) → 5-nitro-2,3-dihydro-1-benzofuran (17403-47-3)

Guidance literature:

With nitric acid; trifluoroacetic acid; at 0 - 20 ℃; for 3.5h;

DOI:10.1021/jm5002502

Reference yield:

3-oxo-2,3-dihydrobenzo[b]furan (7169-34-8) → 5-nitro-2,3-dihydro-1-benzofuran (17403-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride; lithium aluminium tetrahydride / diethyl ether / 0 °C / Reflux

2: silver nitrate; acetyl chloride / acetonitrile; water / 5 h / 0 - 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; silver nitrate; acetyl chloride; In diethyl ether; water; acetonitrile;

DOI:10.1016/j.bmc.2013.04.005

Reference yield: 97.2%

5-nitro-2,3-dihydro-1-benzofuran (17403-47-3) → 2,3-dihydro-1-benzofuran-5-amine (42933-43-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃; for 18h; under 2844.39 Torr;

DOI:10.1021/jm100751q

upstream raw materials:

2.3-dihydrobenzofuran

3-oxo-2,3-dihydrobenzo[b]furan

Downstream raw materials:

2,3-dihydro-1-benzofuran-5-amine

6-nitro-2,3-dihydro-1-benzofuran-5-ylamine

5,6-diamino-2,3-dihydrobenzofuran

6-nitro-2,3-dihydro-1-benzofuran

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