(R)-(1-(4-nitrophenyl))ethanol

Base Information

• Chemical Name: (R)-(1-(4-nitrophenyl))ethanol
• CAS No.: 58287-18-6
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.164
• Mol file: 58287-18-6.mol

Synonyms:(R)-(1-(4-nitrophenyl))ethanol;(alphaR)-alpha-Methyl-4-nitrobenzenemethanol;(R)-(+)-α-(p-Nitrophenyl)ethanol

Chemical Property of (R)-(1-(4-nitrophenyl))ethanol

Chemical Property:

• PSA: 66.05000
• Density: 1.263
• LogP: 2.17130
• Storage Temp.: 2-8°C

Purity/Quality:

99.5% ^*data from raw suppliers

(R)-1-(4-Nitrophenyl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(1-(4-nitrophenyl))ethanol

There total 83 articles about (R)-(1-(4-nitrophenyl))ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-nitrophenyl)ethanone (100-19-6) → (S)-1-[4-nitrophenyl]ethanol (6531-13-1,58287-18-6,99531-06-3,96156-72-8)

Guidance literature:

With glucose dehydrogenase; D-glucose; ketoreductase from Pichia glucozyma; nicotinamide adenine dinucleotide phosphate; In aq. buffer; at 30 ℃; pH=8; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c6ob00047a

Reference yield: 100.0%

(4-nitrophenyl)ethanone (100-19-6) → (1R)-1-(4-nitrophenyl)ethanol (6531-13-1,96156-72-8,99531-06-3,58287-18-6)

Guidance literature:

With (S,S)-RuCl₂(2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)(1,1-dianisyl-2-isopropyl-1,2-ethylenediamine); potassium tert-butylate; hydrogen; In isopropyl alcohol; at 26 - 30 ℃; for 15h; under 6080 Torr;

DOI:10.1021/ja983257u

Reference yield: 97.0%

methyllithium (917-54-4) + 4-nitrobenzaldehdye (555-16-8) → (S)-1-[4-nitrophenyl]ethanol (6531-13-1,58287-18-6,99531-06-3,96156-72-8) + (1R)-1-(4-nitrophenyl)ethanol (6531-13-1,96156-72-8,99531-06-3,58287-18-6)

Guidance literature:

With triisopropoxytitanium(IV) chloride; (S_a)-2'-((S)-hydroxy(phenyl)methyl)-[1,1'-binaphthalen]-2-ol; In diethyl ether; hexane; at -20 ℃; for 0.166667h; enantioselective reaction;

DOI:10.1002/ejoc.201600104

upstream raw materials:

Isopropenyl acetate

1-[4-nitrophenyl]-1-ethanol

(-)-(S)-N,N-dimethyl-1-phenylethylamine

acetic anhydride

Downstream raw materials:

1-[4-nitrophenyl]-1-ethanol

(R)-4-(4-nitrophenyl)pentan-2-one

4-(4-nitrophenyl)pentan-2-one

(-)-1-(4'-nitrophenyl)bromoethane

Refernces

• 1、 G?rbe, Tamás,Gustafson, Karl P. J.,Verho, Oscar,Kervefors, Gabriella,Zheng, Haoquan,Zou, Xiaodong,Johnston, Eric V.,B?ckvall, Jan-E.. "Design of a Pd(0)-CalB CLEA Biohybrid Catalyst and Its Application in a One-Pot Cascade Reaction". . p. 1601 - 1605. Retrieved 2017.
• 2、 Doherty, Simon,Knight, Julian G.,Alshaikh, Hind,Wilson, James,Waddell, Paul G.,Wills, Corinne,Dixon, Casey M.. "Arene-Immobilized Ru(II)/TsDPEN Complexes: Synthesis and Applications to the Asymmetric Transfer Hydrogenation of Ketones". supporting information. p. 226 - 235. Retrieved 2020/12/31.
• 3、 Akhtar, Naved,Antil, Neha,Begum, Wahida,Chauhan, Manav,Kumar, Ajay,Manna, Kuntal,Newar, Rajashree. "Chiral Iron(II)-Catalysts within Valinol-Grafted Metal-Organic Frameworks for Enantioselective Reduction of Ketones". . p. 10450 - 10459. Retrieved 2021/08/31.