4-Iodopyrimidine

Base Information

Chemical Name:4-Iodopyrimidine
CAS No.:31462-57-4
Molecular Formula:C4H3IN2
Molecular Weight:205.98
Hs Code.:
European Community (EC) Number:844-510-9
DSSTox Substance ID:DTXSID70590827
Nikkaji Number:J2.508.736D
Wikidata:Q82484455
Mol file:31462-57-4.mol

Synonyms:4-iodopyrimidine;31462-57-4;MFCD16251620;4-iodo-pyrimidine;6-iodo pyrimidine;SCHEMBL171767;DTXSID70590827;AKOS015892438;SB13069;SY040319;DB-106856;CS-0308688;EN300-127381;J-515581

Suppliers and Price of 4-Iodopyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Iodopyrimidine
50mg
$ 150.00

Medical Isotopes, Inc.
4-iodopyrimidine 97%
1 g
$ 1150.00

J&W Pharmlab
4-Iodo-pyrimidine 96%
500mg
$ 299.00

J&W Pharmlab
4-Iodo-pyrimidine 96%
250mg
$ 199.00

J&W Pharmlab
4-Iodo-pyrimidine 96%
100mg
$ 149.00

J&W Pharmlab
4-Iodo-pyrimidine 96%
50mg
$ 125.00

J&W Pharmlab
4-Iodo-pyrimidine 96%
1g
$ 498.00

J&W Pharmlab
4-Iodo-pyrimidine 96%
5g
$ 1690.00

Crysdot
4-Iodopyrimidine 95+%
5g
$ 1200.00

Crysdot
4-Iodopyrimidine 95+%
1g
$ 380.00

Total 10 raw suppliers

Chemical Property of 4-Iodopyrimidine

Chemical Property:

Melting Point:112 °C (decomp)
Boiling Point:231.6±13.0 °C(Predicted)
PKA:0.07±0.10(Predicted)
PSA：25.78000
Density:2.102±0.06 g/cm3(Predicted)
LogP:1.08120
Storage Temp.:Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Solubility.:Chloroform, DMSO, Methanol
XLogP3:0.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:205.93410
Heavy Atom Count:7
Complexity:57.7

Purity/Quality:

97% ^*data from raw suppliers

4-Iodopyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=CN=C1I
Uses 4-Iodopyrimidine is used as a reactant in the preparation of 1,3,8-triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

Technology Process of 4-Iodopyrimidine

There total 4 articles about 4-Iodopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 289-95-2,25247-63-6
PYRIMIDINE

: 31462-57-4
4-iodopyrimidine

Guidance literature:: PYRIMIDINE; With cadmium(II) chloride-N,N,N',N'-tetramethylethylenediamine; 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at 20 ℃; for 2h;

With iodine; In tetrahydrofuran; regioselective reaction;
DOI:10.1055/s-0028-1083218

Reference yield: 58.0%

: 289-95-2,25247-63-6
PYRIMIDINE

: 31462-57-4
4-iodopyrimidine

: 31462-58-5
5-iodopyrimidine

Guidance literature:: PYRIMIDINE; With 2,2,6,6-tetramethylpiperidin-4-yl heptanoate; 2,2,6,6-tetramethyl-piperidine; n-butyllithium; dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; Inert atmosphere;
DOI:10.1002/chem.201000543

Reference yield: 57.0%

: 289-95-2,25247-63-6
PYRIMIDINE

: 31462-57-4
4-iodopyrimidine

: 2426-94-0
4,4'-bipyrimidine

: 31462-58-5
5-iodopyrimidine

Guidance literature:: PYRIMIDINE; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; zinc(II) chloride; In tetrahydrofuran; hexane; at 25 ℃; for 2.5h;

With iodine; In tetrahydrofuran; hexane; Further stages.;
DOI:10.1021/jo0708341