Synonyms:pyrimidine
98% *data from raw suppliers
Pyrimidine *data from reagent suppliers
There total 89 articles about Pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 85.0%
Reference yield: 70.0%
Reference yield: 55.0%
The study in the literature focuses on the synthesis and antimicrobial activity of 2,4-bis(aryloxy)pyrimidines. The researchers synthesized these compounds by condensing 2,4-dichloropyrimidines with various phenolic compounds in the presence of anhydrous potassium carbonate. The synthesized 2,4-bis(aryloxy)pyrimidines were tested against gram-positive and gram-negative bacteria, as well as a pathogenic strain of yeast. The study found that these compounds exhibited antimicrobial activity, with their effectiveness being largely independent of the substituents in the phenyl ring. The 5-methyl substitution in the pyrimidine ring did not significantly alter the inhibitory activity of the compounds.
The research focuses on the development of an efficient synthetic route for pyrimidine nucleoside analogues, which are compounds with significant pharmaceutical value, particularly as antiviral and antitumor agents. The study reports a convergent chemistry approach using [4+2] cycloaddition reactions between glycosyl isothiocyanates (3a-f) and diazadienium salt 5, yielding β-D-uracil analogues (7a-f) with good yields and total regiocontrol. The process involves the preparation of glycosyl isothiocyanates from acetylated or benzoylated glycosyl bromides and the synthesis of diazadienium iodide 5 from vinylthioamide 4. The synthesized compounds were fully characterized using IR, HRMS, and NMR techniques.
The study explores the development of small-molecule GLP-1 receptor agonists for treating type 2 diabetes. The researchers synthesized two series of pyrimidine derivatives. The first series involved substituting positions 2 and 4 of pyrimidines with various groups, while the second series included pyrimidines with urea and Schiff base linkers. These compounds were tested for their ability to increase insulin secretion in cultured βTC6 cells. Key findings include compounds 3a and 10a significantly boosting insulin secretion in both the absence and presence of 2.8 mM glucose, with compound 10a showing effects similar to the potent drug exenatide. The study highlights the potential of these pyrimidine analogs as orally available GLP-1 receptor agonists, providing a foundation for further research into small-molecule therapeutics for diabetes.
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