(R)-2-Phenylmorpholine

Base Information

• Chemical Name: (R)-2-Phenylmorpholine
• CAS No.: 1225376-02-2
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• DSSTox Substance ID: DTXSID80359088
• Wikidata: Q82140103
• Mol file: 1225376-02-2.mol

Synonyms:(R)-2-Phenylmorpholine;1225376-02-2;(2R)-2-phenylmorpholine;MFCD18249849;SCHEMBL4536932;DTXSID80359088;Morpholine, 2-phenyl-, (2R)-;AMY21609;AKOS016843519;AS-47278;CS-0139724;F13065;EN300-3032919;A891105

Chemical Property of (R)-2-Phenylmorpholine

Chemical Property:

• PSA: 21.26000
• LogP: 1.67630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 132

Purity/Quality:

97% ^*data from raw suppliers

(2R)-2-Phenyl-morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)C2=CC=CC=C2
• Isomeric SMILES: C1CO[C@@H](CN1)C2=CC=CC=C2
• Uses: (2R)-2-Phenyl-morpholine is a useful research chemical.

Technology Process of (R)-2-Phenylmorpholine

There total 6 articles about (R)-2-Phenylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(R)-2-phenyl-4-(4-methylbenzenesulfonyl)morpholine (1225375-82-5) → (R)-2-phenylmorpholine (1225376-02-2)

Guidance literature:

With pyrrolidine; samarium diiodide; water; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/jo1003295

Reference yield:

C10H11NO2 → (R)-2-phenylmorpholine (1225376-02-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2009.02.033

Reference yield:

(S)-styrene oxide (20780-54-5) → (R)-2-phenylmorpholine (1225376-02-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂O / 5 h / Ambient temperature

2: pyridine / 1.) 0 deg C; 2.) room tempetature, 1 d

3: NaOH/MeOH / CHCl₃ / 0.5 h

4: Na / pentan-1-ol / 3 h / Heating

With methanol; sodium hydroxide; sodium; In pyridine; pentan-1-ol; chloroform; water;

DOI:10.1016/0040-4020(80)87009-8

upstream raw materials:

(S)-4-(4-methylbenzenesulfonyl)-2-phenylmorpholine

(S)-styrene oxide

(S)-2-(2-hydroxy-ethylamino)-1-phenyl-ethanol

(R)-2-phenyl-4-(4-methylbenzenesulfonyl)morpholine

Downstream raw materials:

3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

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