3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

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Chemical Name:3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
CAS No.:1374667-69-2
Molecular Formula:C₂₂H₂₃F₃N₄O
Molecular Weight:416.446
Hs Code.:

Synonyms:3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

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Chemical Property of 3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

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Technology Process of 3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

There total 9 articles about 3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.5%

: 1225376-02-2
(R)-2-phenylmorpholine

: 1254982-03-0
3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carbaldehyde

: 1374667-69-2
3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 343781-36-2
2,4-dichloro-3-iodo-pyridine

: 1374667-69-2
3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(l) iodide / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed vessel

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.03 h / 0 °C

2.2: 1 h / 20 °C

3.1: hydrazine hydrate / 1,4-dioxane; water / 0.5 h / 160 °C / Microwave irradiation

4.1: triethylamine / dichloromethane / 0.33 h / 0 °C

5.1: trichlorophosphate / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

6.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.22 h / 150 °C / Microwave irradiation

7.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation

With sodium periodate; copper(l) iodide; osmium(VIII) oxide; sodium tris(acetoxy)borohydride; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1374667-69-2
3-(cyclopropylmethyl)-7-[[(2R)-2-phenyl-4-morpholinyl]methyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: copper(l) iodide / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed vessel

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.03 h / 0 °C

3.2: 1 h / 20 °C

4.1: hydrazine hydrate / 1,4-dioxane; water / 0.5 h / 160 °C / Microwave irradiation

5.1: triethylamine / dichloromethane / 0.33 h / 0 °C

6.1: trichlorophosphate / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

7.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.22 h / 150 °C / Microwave irradiation

8.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

9.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation

With sodium periodate; copper(l) iodide; osmium(VIII) oxide; n-butyllithium; sodium tris(acetoxy)borohydride; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;