4-chloro-8-tosyloxyquinoline

Base Information

• Chemical Name: 4-chloro-8-tosyloxyquinoline
• CAS No.: 1022094-18-3
• Molecular Formula: C16H12ClNO3S
• Molecular Weight: 333.79
• Mol file: 1022094-18-3.mol

Synonyms:4-Chloroquinolin-8-yl 4-methylbenzenesulfonate;4-chloro-8-tosyloxyquinoline;

Chemical Property of 4-chloro-8-tosyloxyquinoline

Chemical Property:

• PSA: 64.64000
• LogP: 5.04510

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloroquinolin-8-yl4-methylbenzenesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-8-tosyloxyquinoline

There total 3 articles about 4-chloro-8-tosyloxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-hydroxyquinolin-8-yl 4-methylbenzenesulfonate → (4-chloroquinolin-8-yl)-4-methylbenzenesulfonate (1022094-18-3)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

DOI:10.1002/jhet.5570450247

Reference yield:

4,8-dihydroxyquinoline (14959-84-3) → (4-chloroquinolin-8-yl)-4-methylbenzenesulfonate (1022094-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; acetone / 3 h / 20 °C

2: trichlorophosphate / 1 h / Reflux; Inert atmosphere

With sodium hydroxide; trichlorophosphate; In water; acetone;

DOI:10.1039/c5cc06095h

Reference yield:

xanthurenic acid (59-00-7) → (4-chloroquinolin-8-yl)-4-methylbenzenesulfonate (1022094-18-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenylether / 2.5 h / 250 °C

2: sodium hydroxide / water; acetone / 3 h / 20 °C

3: trichlorophosphate / 1 h / Reflux; Inert atmosphere

With sodium hydroxide; trichlorophosphate; In diphenylether; water; acetone;

DOI:10.1039/c5cc06095h

upstream raw materials:

4,8-dihydroxyquinoline

xanthurenic acid

Downstream raw materials:

4-pyrrolidinyl-8-hydroxyquinoline

N-tosylpyrrolidine

4-(1H-pyrazol-1-yl)quinolin-8-yl 4-methylbenzenesulfonate

4-chloro-8-hydroxyquinoline