1-[(4-methylphenyl)sulfonyl]pyrrolidine

Base Information

• Chemical Name: 1-[(4-methylphenyl)sulfonyl]pyrrolidine
• CAS No.: 6435-78-5
• Molecular Formula: C11H15 N O2 S
• Molecular Weight: 225.312
• Hs Code.: 2933990090
• Mol file: 6435-78-5.mol

Synonyms:Pyrrolidine,1-(p-tolylsulfonyl)- (6CI,7CI,8CI); 1-Tosylpyrrolidine;N-(p-Tolylsulfonyl)pyrrolidine; NSC 61572

Chemical Property of 1-[(4-methylphenyl)sulfonyl]pyrrolidine

Chemical Property:

• Boiling Point: 352.9°Cat760mmHg
• Flash Point: 167.2°C
• PSA: 45.76000
• Density: 1.229g/cm³
• LogP: 2.79820

Purity/Quality:

97% ^*data from raw suppliers

1-Tosylpyrrolidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(4-methylphenyl)sulfonyl]pyrrolidine

There total 73 articles about 1-[(4-methylphenyl)sulfonyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + sodium 4-methylbenzenesulfinate (824-79-3) → N-tosylpyrrolidine (6435-78-5)

Guidance literature:

With sodium hypochlorite; In water; Ambient temperature;

DOI:10.1021/jo00338a005

Reference yield: 100.0%

N-(p-methoxyphenyl)-N-(trifluoromethanesulfonyl)-N'-(p-toluenesulfonyl)-1,4-butanediamine (1243273-51-9) → N-tosylpyrrolidine (6435-78-5)

Guidance literature:

With potassium phosphate; In N,N-dimethyl-formamide; at 150 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol101541p

Reference yield: 99.0%

N-(3-hydroxybutyl)-4-methylbenzenesulfonamide (78521-69-4) → N-tosylpyrrolidine (6435-78-5)

Guidance literature:

With tris(pentafluorophenyl)borate; In nitromethane; at 100 ℃; for 4h; chemoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/c4ob01265h

upstream raw materials:

pyrrolidine

p-toluenesulfonyl chloride

1,4-dibromo-butane

toluene-4-sulfonamide

Downstream raw materials:

1-<(4-methyl-phenyl)sulfonyl>-2-methoxy-pyrrolidine

pyrrolidine

succinic acid

4-(aminosulfonyl)-benzoic acid