1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

Base Information

Chemical Name:1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole
CAS No.:127000-90-2
Molecular Formula:C₁₂H₁₁F₂N₃O
Molecular Weight:251.236
Hs Code.:
European Community (EC) Number:806-540-0
UNII:D1JO8189W7
Nikkaji Number:J424.587C
Wikidata:Q76415168
Mol file:127000-90-2.mol

Synonyms:127000-90-2;1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole;132563-77-0;124627-86-7;(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazole-1-yl)methyl]oxirane;1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl]methyl]-1,2,4-triazole;D1JO8189W7;1-{[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl]methyl}-1H-1,2,4-triazole;1. 1-(((2R, 3S)-2-(2,4-difluorophenyl)-3-Methyloxiran-2-yl) Methyl)-1H-1,2,4-triazole;1H-1,2,4-Triazole, 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl]methyl]-;1-[(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYLMETHYL]-1H-[1,2,4]TRIAZOLE;1-((2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole, (2R-cis)-;1H-1,2,4-Triazole, 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl)methyl)-;1H-1,2,4-Triazole, 1-((2-(2,4-difluorophenyl)-3-methyloxiranyl)methyl)-, (2R-cis)-;rel-1-(((2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-METHYLOXIRAN-2-YL)METHYL)-1H-1,2,4-TRIAZOLE;MFCD09833867;1-(((2r,3s)-2-(2,4-difluorophenyl)-3-methyloxiranyl)methyl)-1h-1,2,4-triazole;1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-Methyloxiranyl]Methyl]-1H-1,2,4-Triazole;SCHEMBL300482;UNII-D1JO8189W7;Phosphoric acidtri-o-tolyl ester;AKOS016023711;AS-30125;CS-0012900;D72495;A854826;A1-00273;(2 R,3 S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1 H-1,2,4-triazol-1-yl)methyl]oxirane;(2R, 3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane;(2R,3S)-2-(2,4-Difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-yl)methyloxirane;(2R,3S)-2-(2,4-Difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)oxirane;(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1 H-1,2,4-triazol-1-yl)methyl]oxirane;(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane;(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol1-yl)methyl]oxirane;(2R,3S)-2-(2,4Difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)oxirane;1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyl oxiran-2-yl)methyl)-1H-1,2,4-triazol;1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazol;1-[(2R,3S)-2-(2,4-Difluorophenyl)-2,3-epoxybutan-1-yl]-1H-1,2,4-triazole;1-{[(2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-METHYLOXIRAN-2-YL]METHYL-1H-1,2,4-TRIAZOLE

Suppliers and Price of 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[[(2R,3S)-2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole
2.5g
$ 520.00

Matrix Scientific
(2R,3S)-2-(2,4-Difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazole-1-yl)methyl]oxirane 96%
1g
$ 800.00

Chemenu
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole 95%
1000g
$ 7200.00

AK Scientific
1-(((2R,3S)-2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole
1g
$ 1130.00

Acrotein
1-[[(2R,3S)-2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole 97%
1g
$ 124.67

Acrotein
1-[[(2R,3S)-2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole 97%
5g
$ 374.00

ACHEMBLOCK
1-{[(2R,3S)-2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl]methyl}-1H-1,2,4-triazole 97%
1G
$ 250.00

ACHEMBLOCK
1-{[(2R,3S)-2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl]methyl}-1H-1,2,4-triazole 97%
250MG
$ 100.00

A1 Biochem Labs
(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazole-1-yl)methyl]oxirane 96%
5 g
$ 600.00

Total 107 raw suppliers

Chemical Property of 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

Chemical Property:

Appearance/Colour:White or off-white Solid
Boiling Point:371.6±52.0 °C(Predicted)
PKA:2.75±0.10(Predicted)
PSA：43.24000
Density:1.41±0.1 g/cm3 (20 oC 760 Torr)
LogP:1.87050
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:251.08701831
Heavy Atom Count:18
Complexity:320

Purity/Quality:

99.0% ^*data from raw suppliers

1-[[(2R,3S)-2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)F)F
Isomeric SMILES:C[C@H]1[C@](O1)(CN2C=NC=N2)C3=C(C=C(C=C3)F)F

Technology Process of 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

There total 72 articles about 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 132507-89-2,132507-94-9,135270-05-2,135270-11-0,135272-36-5,133775-25-4
(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

Guidance literature:: (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 12h; enantioselective reaction;
DOI:10.1021/acs.orglett.1c02588