1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one

Base Information

• Chemical Name: 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one
• CAS No.: 132563-81-6
• Molecular Formula: C₁₄H₁₆F₂O₃
• Molecular Weight: 270.276
• Mol file: 132563-81-6.mol

Synonyms:1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one

Chemical Property of 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one

There total 25 articles about 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one (126918-16-9) → (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0)

Guidance literature:

With pyridinium p-toluenesulfonate; Ambient temperature;

DOI:10.1016/S0040-4039(00)74391-7

Reference yield: 98.0%

2,4-difluorobromobenzene (348-57-2) + C12H21NO4 → 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one (132563-81-6)

Guidance literature:

2,4-difluorobromobenzene; With magnesium; In tetrahydrofuran; at 20 - 40 ℃; for 1h;

C₁₂H₂₁NO₄; In tetrahydrofuran; for 0.25h;

Reference yield: 98.0%

(R)-1-(1 piperidinyl)-2-(2-tetrahydropyranyl)oxy-1-propanone + (2,4-difluorophenyl)magnesium bromide (144025-04-7) → (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; for 4.25h; Large scale;

upstream raw materials:

3,4-dihydro-2H-pyran

1-(2,4-difluorophenyl)-2-hydroxy-1-propanone

1,3-Difluorobenzene

2-bromo-1-(2,4-difluorophenyl)-1-propanone

Downstream raw materials:

(2S^*,3R^*)-2-(2,4-Difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(tetrahydropyran-2-yloxy)-2-butanol

(2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,2,3-butanetriol

Methanesulfonic acid (S)-1-[(R)-2-(2,4-difluoro-phenyl)-oxiranyl]-ethyl ester

(2S,3S)-2-(2,4-Difluoro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-butane-1,2-diol