6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester
• CAS No.: 1150566-27-0
• Molecular Formula: C9 H8 Cl N3 O2
• Molecular Weight: 225.634
• Hs Code.: 2933990090
• Mol file: 1150566-27-0.mol

Synonyms:ethyl 6-chloroimidazo[1,2-b]pyridazine-3-ncarboxylate; Imidazo[1,2-b]pyridazine-3-carboxylic acid,6-chloro-,ethyl ester; 6-chloro-imidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

Chemical Property of 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

Chemical Property:

• PKA: 0.88±0.30(Predicted)
• PSA: 56.49000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 1.55940
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl6-Chloroimidazo[1,2-b]pyridazine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester is mainly used as pharmaceutical intermediates.

Technology Process of 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

There total 11 articles about 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylformimidamide + ethyl bromoacetate (105-36-2) → 6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1150566-27-0)

Guidance literature:

(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylformimidamide; ethyl bromoacetate; In acetonitrile; at 80 ℃; for 3h;

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2020.112092

Reference yield: 77.0%

3-chloro-6-(dimethylamino-methyleneamino)-1-ethoxycarbonylmethyl-pyridazin-1-ium bromide (1150566-26-9) → 6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1150566-27-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 4h;

Reference yield: 63.2%

6-chloro-pyridazin-3-ylamine (5469-69-2) + ethyl 3-ethoxyacrylate (5941-55-9) → 6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1150566-27-0)

Guidance literature:

ethyl 3-ethoxyacrylate; With N-Bromosuccinimide; In 1,4-dioxane; water; at -10 - 25 ℃; for 1h;

6-chloro-pyridazin-3-ylamine; In 1,4-dioxane; water; at 80 ℃; for 1h;

upstream raw materials:

3-chloro-6-(dimethylamino-methyleneamino)-1-ethoxycarbonylmethyl-pyridazin-1-ium bromide

N'-(6-chloropyridazin-3-yl)-N,N-dimethylmethanimidamide

6-chloro-pyridazin-3-ylamine

ethyl 2-chloro-3-oxopropanoate

Downstream raw materials:

6-(4-fluoro-benzylamino)-imidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

6-chloro-imidazo[1,2-b]pyridazine-3-carboxylic acid phenylamide

6-(3,4-dichloro-benzylamino)-imidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

6-(3,4-dichloro-benzylamino)-imidazo[1,2-b]pyridazine-3-carboxylic acid 3,4-dichlorobenzylamide

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