6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole

Base Information

• Chemical Name: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole
• CAS No.: 1002309-47-8
• Molecular Formula: C13H16BNO2S
• Molecular Weight: 261.153
• Hs Code.: 2934999090
• Mol file: 1002309-47-8.mol

Synonyms:6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole;Benzothiazole-6-boronic acid, pinacol ester

Chemical Property of 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole

Chemical Property:

• Boiling Point: 380.6±15.0 °C(Predicted)
• PKA: 0.53±0.10(Predicted)
• PSA: 59.59000
• Density: 1.17±0.1 g/cm3(Predicted)
• LogP: 2.59550
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benzothiazole-6-boronic acid, pinacol ester

Technology Process of 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole

There total 6 articles about 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-bromo-1,3-benzothiazole (53218-26-1) + bis(pinacol)diborane (73183-34-3) → 6‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1,3‐benzothiazole (1002309-47-8)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 95 ℃; for 18h; Inert atmosphere; Sealed flask;

Reference yield: 90.0%

6-bromo-1,3-benzothiazole (53218-26-1) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 6‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1,3‐benzothiazole (1002309-47-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 46.0%

1-(benzo[d]thiazol-6-yl)butan-1-one O-perfluorobenzoyl oxime + bis(pinacol)diborane (73183-34-3) → 6‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1,3‐benzothiazole (1002309-47-8)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; 2-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; tris<3,5-bis(trifluoromethyl)phenyl>phosphane; palladium dichloride; In 1,2-dichloro-ethane; at 120 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202006740

upstream raw materials:

6-bromo-1,3-benzothiazole

bis(pinacol)diborane

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

Downstream raw materials:

ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

Refernces

• 1、 -. "CDK6/DYRK2 Double-target inhibitor as well as preparation method and application thereof". Paragraph 0041-0042. . Retrieved 2021/02/24.
• 2、 -. "FUSED RING DERIVATIVE AS A2A RECEPTOR INHIBITOR". Paragraph 0145-0147. . Retrieved 2020/08/09.