ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

Base Information

Chemical Name:ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate
CAS No.:1168134-91-5
Molecular Formula:C₂₅H₂₈ClNO₃S
Molecular Weight:458.021
Hs Code.:

Synonyms:ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

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Chemical Property of ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

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Technology Process of ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

There total 5 articles about ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1002309-47-8
6‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1,3‐benzothiazole

: 1168134-90-4
ethyl 2-(3-bromo-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

: 1168134-91-5
ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 20 - 80 ℃; for 14h;

Reference yield:

: 193357-36-7
3-chloro-4-hydroxyphenylacetic acid ethyl ester

: 1168134-91-5
ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / chloroform / 1 h / 0 °C

2.1: potassium carbonate / dimethyl sulfoxide / 4 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 1 h / 0 °C

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 14 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; potassium carbonate; caesium carbonate; In chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 29121-25-3
ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

: 1168134-91-5
ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuryl dichloride / methanol; dichloromethane / 5 h / Reflux

2.1: potassium carbonate / dimethyl sulfoxide / 4 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 1 h / 0 °C

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 14 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuryl dichloride; sodium hydride; potassium carbonate; caesium carbonate; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;