4-(5-BROMOTHIAZOL-2-YL)MORPHOLINE

Base Information

• Chemical Name: 4-(5-BROMOTHIAZOL-2-YL)MORPHOLINE
• CAS No.: 933728-73-5
• Molecular Formula: C7H9BrN2OS
• Molecular Weight: 249.131
• Hs Code.: 2934999090
• Mol file: 933728-73-5.mol

Synonyms:4-(5-BROMOTHIAZOL-2-YL)MORPHOLINE

Chemical Property of 4-(5-BROMOTHIAZOL-2-YL)MORPHOLINE

Chemical Property:

• Boiling Point: 348.6±52.0 °C(Predicted)
• PKA: 3.36±0.50(Predicted)
• PSA: 53.60000
• Density: 1.642±0.06 g/cm3(Predicted)
• LogP: 1.80720

Purity/Quality:

97% ^*data from raw suppliers

4-(5-Bromothiazol-2-yl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(5-BROMOTHIAZOL-2-YL)MORPHOLINE

There total 3 articles about 4-(5-BROMOTHIAZOL-2-YL)MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-bromo-1,3-thiazole (3034-55-7) + 4-(benzoyloxy)morpholine (5765-65-1) → 4-(5-bromothiazol-2-yl)morpholine (933728-73-5)

Guidance literature:

5-bromo-1,3-thiazole; With bis(2,2,6,6-tetramethyl-1-piperidyl)zinc; In tetrahydrofuran; toluene; at 20 ℃; for 1h; Inert atmosphere;

4-(benzoyloxy)morpholine; With copper diacetate; In tetrahydrofuran; toluene; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201311029

Reference yield:

morpholine (110-91-8,99108-56-2) + 2,5-dibromo-1,3-thiazole (4175-78-4) → 4-(5-bromothiazol-2-yl)morpholine (933728-73-5)

Guidance literature:

With triethylamine; In ethanol; at 150 ℃; for 2h;

Reference yield:

→ 4-(5-bromothiazol-2-yl)morpholine (933728-73-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃; for 8h;

upstream raw materials:

morpholine

2,5-dibromo-1,3-thiazole

5-bromo-1,3-thiazole

4-(benzoyloxy)morpholine