Technology Process of 3-({[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazole
There total 17 articles about 3-({[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tungstate (VI) dihydrate; sulfuric acid; dihydrogen peroxide;
In
methanol;
at 25 ℃;
for 5h;
Reagent/catalyst;
- Guidance literature:
-
3-[[[5-(hydroxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethylisoxazole; Chlorodifluoromethane;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 6h;
With
sodium tungstate (VI) dihydrate; sulfuric acid; dihydrogen peroxide;
In
methanol;
for 6h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 2.58 h / 24 °C
1.2: 16 h / 20 °C
1.3: 16 h / 14 - 20 °C
2.1: sodium hydroxide / acetonitrile / 1.67 h / 20 - 24 °C
2.2: 60.75 h / 5 - 20 °C
3.1: dihydrogen peroxide / sodium tungstate (VI) dihydrate / acetic acid / 16.33 h / 20 - 34 °C
With
dihydrogen peroxide; sodium hydroxide;
sodium tungstate (VI) dihydrate;
In
water; acetic acid; acetonitrile;