Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate

Base Information

Chemical Name:Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate
CAS No.:74840-38-3
Molecular Formula:C8H9BrN2O2S
Molecular Weight:277.142
Hs Code.:2933599090
DSSTox Substance ID:DTXSID60503789
Wikidata:Q82357834
Mol file:74840-38-3.mol

Synonyms:74840-38-3;Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate;ethyl 5-bromo-2-methylsulfanylpyrimidine-4-carboxylate;Ethyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate;ETHYL 5-BROMO-2-(METHYLTHIO)-PYRIMIDINE-4-CARBOXYLATE;4-Pyrimidinecarboxylic acid, 5-bromo-2-(methylthio)-, ethyl ester;Ethyl5-bromo-2-(methylthio)pyrimidine-4-carboxylate;SCHEMBL2160733;Ethyl 5-bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylate;DTXSID60503789;ZCA84038;MFCD18642497;AKOS016005953;SB60523;AS-69000;CS-0151676;C76391;A917310

Suppliers and Price of Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl 5-bromo-2-(methylthio)-pyrimidine-4-carboxylate 95+%
1g
$ 538.00

Matrix Scientific
Ethyl 5-bromo-2-(methylthio)-pyrimidine-4-carboxylate 95+%
250mg
$ 244.00

Crysdot
Ethyl5-bromo-2-(methylthio)pyrimidine-4-carboxylate 95+%
1g
$ 220.00

Crysdot
Ethyl5-bromo-2-(methylthio)pyrimidine-4-carboxylate 95+%
5g
$ 749.00

Chemenu
Ethyl5-bromo-2-(methylthio)-pyrimidine-4-carboxylate 95%
5g
$ 707.00

American Custom Chemicals Corporation
ETHYL-5-BROMO-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE 95.00%
5MG
$ 499.05

Ambeed
Ethyl5-bromo-2-(methylthio)pyrimidine-4-carboxylate 95+%
5g
$ 269.00

Ambeed
Ethyl5-bromo-2-(methylthio)pyrimidine-4-carboxylate 95+%
1g
$ 78.00

Ambeed
Ethyl5-bromo-2-(methylthio)pyrimidine-4-carboxylate 95+%
250mg
$ 34.00

AK Scientific
Ethyl5-bromo-2-(methylthio)pyrimidine-4-carboxylate
100mg
$ 126.00

Total 7 raw suppliers

Chemical Property of Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate

Chemical Property:

PSA：77.38000
LogP:2.13770
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:275.95681
Heavy Atom Count:14
Complexity:206

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 5-bromo-2-(methylthio)-pyrimidine-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=NC(=NC=C1Br)SC

Technology Process of Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate

There total 1 articles about Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 50593-92-5
5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid

: 64-17-5
ethanol

: 74840-38-3
ethyl 5-bromo-2-methylthio-4-pyrimidinecarboxylate

Guidance literature:: With hydrogenchloride; at 60 - 70 ℃; for 1h;
DOI:10.1135/cccc19800539

Reference yield: 84.0%

: 3900-89-8
2-Chlorobenzeneboronic acid

: 74840-38-3
ethyl 5-bromo-2-methylthio-4-pyrimidinecarboxylate

: 311335-75-8
5-(2-Chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 105 ℃; for 4h;

Reference yield:

: 74840-38-3
ethyl 5-bromo-2-methylthio-4-pyrimidinecarboxylate

: 311334-77-7
5-(2-Chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 105 °C

2.1: sodium hydroxide / ethanol / 1 h / 20 °C

2.2: pH 1

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 5 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide;