952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole

Base Information

• Chemical Name: 952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole
• CAS No.: 952511-48-7
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• Mol file: 952511-48-7.mol

Synonyms:952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole;5-broMo-4-Methyl-1H-benzo[d]iMidazole

Chemical Property of 952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole

Chemical Property:

• Boiling Point: 418.3±25.0 °C(Predicted)
• PKA: 11.60±0.30(Predicted)
• PSA: 28.68000
• Density: 1.654±0.06 g/cm3(Predicted)
• LogP: 2.63380
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-bromo-4-methyl-1H-benzo[d]imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole

There total 6 articles about 952511-48-7 5-broMo-4-Methyl-1H-benzo[d]iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

formic acid (64-18-6) + 4-bromo-3-methyl-1,2-benzenediamine (952511-74-9) → 5-bromo-4-methyl-1H-benzo[d]imidazole (952511-48-7)

Guidance literature:

With hydrogenchloride; water; at 60 ℃; for 12h;

Reference yield: 73.0%

orthoformic acid triethyl ester (122-51-0) + 1-bromo-2-methyl-3,4-dinitrobenzene (290353-57-0) → 5-bromo-4-methyl-1H-benzo[d]imidazole (952511-48-7)

Guidance literature:

1-bromo-2-methyl-3,4-dinitrobenzene; With ethanol; tin(ll) chloride; at 50 ℃; for 2h;

orthoformic acid triethyl ester; at 20 - 70 ℃; for 0.5h;

Reference yield:

2-bromo-6-nitrotoluene (55289-35-5) → 5-bromo-4-methyl-1H-benzo[d]imidazole (952511-48-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 0 - 20 °C

2: tin(II) chloride dihdyrate / ethanol; ethyl acetate / 12 h / 80 °C

3: hydrogenchloride; water / 12 h / 60 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; water; nitric acid; In ethanol; ethyl acetate;

upstream raw materials:

orthoformic acid triethyl ester

1-bromo-2-methyl-3,4-dinitrobenzene

formic acid

4-bromo-3-methyl-1,2-benzenediamine

Downstream raw materials:

7-methyl-1H-benzimidazole-6-carbonitrile

5-Bromo-4-methyl-1-(triphenylmethyl)-1H-benzimidazole

4-methyl-1H-benzo[d]imidazole-5-carbonitrile

Refernces

• 1、 -. "SERINE/THREONINE PAK1 INHIBITORS". Page/Page column 143. . Retrieved 2013/03/26.
• 2、 -. "Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor". Page/Page column 22. . Retrieved 2009/07/03.