4-(Aminomethyl)thiophene-2-carbonitrile

Base Information

Chemical Name:4-(Aminomethyl)thiophene-2-carbonitrile
CAS No.:232280-77-2
Molecular Formula:C₆H₆N₂S
Molecular Weight:138.193
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40453314
Nikkaji Number:J1.691.950K
Wikidata:Q82274431
Mol file:232280-77-2.mol

Synonyms:4-(aminomethyl)thiophene-2-carbonitrile;232280-77-2;4-AMINOMETHYL-THIOPHENE-2-CARBONITRILE;2-Thiophenecarbonitrile, 4-(aminomethyl)-;4-(aminomethyl)-2-thiophenecarbonitrile;SCHEMBL5988843;DTXSID40453314;WELJMDZGAZGMIM-UHFFFAOYSA-N;MFCD08457572;AKOS006292077;SB35754;CS-0450177;FT-0692328;A816631

Suppliers and Price of 4-(Aminomethyl)thiophene-2-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
4-Aminomethyl-thiophene-2-carbonitrile 96%
50mg
$ 156.00

Crysdot
4-(Aminomethyl)thiophene-2-carbonitrile 95+%
1g
$ 635.00

Crysdot
4-(Aminomethyl)thiophene-2-carbonitrile 95+%
5g
$ 1692.00

Crysdot
4-(Aminomethyl)thiophene-2-carbonitrile 95+%
25g
$ 4708.00

Crysdot
4-(Aminomethyl)thiophene-2-carbonitrile 95+%
10g
$ 2634.00

Chemenu
4-(Aminomethyl)thiophene-2-carbonitrile 95%
10g
$ 2482.00

Chemenu
4-(Aminomethyl)thiophene-2-carbonitrile 95%
5g
$ 1594.00

Chemenu
4-(Aminomethyl)thiophene-2-carbonitrile 95%
1g
$ 599.00

American Custom Chemicals Corporation
4-AMINOMETHYL THIOPHENE-2-CARBONITRILE 95.00%
5MG
$ 498.18

Alichem
4-(Aminomethyl)thiophene-2-carbonitrile
25g
$ 6633.00

Total 12 raw suppliers

Chemical Property of 4-(Aminomethyl)thiophene-2-carbonitrile

Chemical Property:

PSA：78.05000
LogP:1.77878
Storage Temp.:2-8°C
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:138.02516937
Heavy Atom Count:9
Complexity:137

Purity/Quality:

97% ^*data from raw suppliers

4-Aminomethyl-thiophene-2-carbonitrile 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(SC=C1CN)C#N

Technology Process of 4-(Aminomethyl)thiophene-2-carbonitrile

There total 5 articles about 4-(Aminomethyl)thiophene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 203792-24-9
4-N,N-bis(tert-butoxycarbonyl)aminomethyl-2-cyanothiophene

: 232280-77-2
4-aminomethyl-thiophene-2-carbonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00093-8

Reference yield:

: 18799-85-4
5-iodo-thiophene-3-carboxaldehyde

: 232280-77-2
4-aminomethyl-thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol / 20 °C

2: dimethylformamide / Heating

3: CBr₄; PPh₃ / CH₂Cl₂

4: NaH / tetrahydrofuran

5: TFA / CH₂Cl₂

With sodium tetrahydroborate; carbon tetrabromide; sodium hydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 4: Gabriel-type amination;
DOI:10.1016/S0960-894X(02)00093-8

Reference yield:

: 186552-07-8
4-bromomethyl-thiophene-2-carbonitrile

: 232280-77-2
4-aminomethyl-thiophene-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: TFA / CH₂Cl₂

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: Gabriel-type amination;
DOI:10.1016/S0960-894X(02)00093-8