pyrrolidin-1-yl(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanone

Base Information

• Chemical Name: pyrrolidin-1-yl(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanone
• CAS No.: 940314-18-1
• Molecular Formula: C16H23BN2O3
• Molecular Weight: 302.181
• Hs Code.: 2934999090
• Mol file: 940314-18-1.mol

Synonyms:1-PYRROLIDINYL[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2-PYRIDINYL]-METHANONE;pyrrolidin-1-yl(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanone

Chemical Property of pyrrolidin-1-yl(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanone

Chemical Property:

• PSA: 51.66000
• LogP: 1.55470

Purity/Quality:

99% ^*data from raw suppliers

Pyrrolidin-1-yl-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-methanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of pyrrolidin-1-yl(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanone

There total 2 articles about pyrrolidin-1-yl(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-bromopyridin-2-yl)(pyrrolidin-1-yl)methanone (742085-70-7) + bis(pinacol)diborane (73183-34-3) → 2-(pyrrolidin-1-ylcarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (940314-18-1) + C10H13BN2O3

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 110 ℃; for 2h; Inert atmosphere;

Reference yield:

(5-bromopyridin-2-yl)(pyrrolidin-1-yl)methanone (742085-70-7) → 2-(pyrrolidin-1-ylcarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (940314-18-1)

Guidance literature:

With potassium acetate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis(diphenylphosphino)ferrocene; In 1,4-dioxane; dichloromethane; at 80 ℃;

Reference yield:

8-(5-bromo-2-fluorophenyl)-2-(cis-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one + 2-(pyrrolidin-1-ylcarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (940314-18-1) → 8-{2-fluoro-5-[6-(pyrrolidin-1-ylcarbonyl)pyridin-3-yl]phenyl}-2-(cis-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 120 ℃; for 0.333333h;

upstream raw materials:

(5-bromopyridin-2-yl)(pyrrolidin-1-yl)methanone

bis(pinacol)diborane