(5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone

Base Information

• Chemical Name: (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone
• CAS No.: 742085-70-7
• Molecular Formula: C10H11 Br N2 O
• Molecular Weight: 255.114
• Hs Code.: 2933990090
• Mol file: 742085-70-7.mol

Synonyms:Pyrrolidine,1-[(5-bromo-2-pyridinyl)carbonyl]- (9CI);5-Bromo-2-[(1-pyrrolidinyl)carbonyl]pyridine

Chemical Property of (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone

Chemical Property:

• Vapor Pressure: 6.59E-06mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 377.8ºC at 760 mmHg
• Flash Point: 182.3ºC
• PSA: 33.20000
• Density: 1.534g/cm3
• LogP: 2.01800
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Bromopyridin-2-ylcarbonyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone

There total 4 articles about (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

pyrrolidine (123-75-1) + 5-bromoisonicotinic acid (30766-11-1) → (5-bromopyridin-2-yl)(pyrrolidin-1-yl)methanone (742085-70-7)

Guidance literature:

5-bromoisonicotinic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 0.25h; sarstedt tube;

pyrrolidine; In dichloromethane; for 1h;

Reference yield:

pyrrolidine (123-75-1) + 2,5-dibromopyridine (624-28-2) + carbon monoxide (201230-82-2) → (5-bromopyridin-2-yl)(pyrrolidin-1-yl)methanone (742085-70-7)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In toluene; at 70 ℃; for 6h; under 3800.26 Torr;

Reference yield:

5-bromopyridine-2-carbonyl chloride (137178-88-2) + pyrrolidine (123-75-1) → (5-bromopyridin-2-yl)(pyrrolidin-1-yl)methanone (742085-70-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

upstream raw materials:

pyrrolidine

2,5-dibromopyridine

carbon monoxide

5-bromopyridine-2-carbonyl chloride

Downstream raw materials:

2-(pyrrolidin-1-ylcarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine