7,8-difluorochroman-4-one

Base Information

• Chemical Name: 7,8-difluorochroman-4-one
• CAS No.: 890840-90-1
• Molecular Formula: C₉H₆F₂O₂
• Molecular Weight: 184.142
• Hs Code.: 2932990090
• Mol file: 890840-90-1.mol

Synonyms:4H-1-benzopyran-4-one, 7,8-difluoro-2,3-dihydro-; 7,8-Difluoro-2,3-dihydro-4H-chromen-4-one

Chemical Property of 7,8-difluorochroman-4-one

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 293.192°C at 760 mmHg
• Flash Point: 127.01°C
• PSA: 26.30000
• Density: 1.393g/cm³
• LogP: 1.93000
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

7,8-Difluorochroman-4-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,8-difluorochroman-4-one

There total 3 articles about 7,8-difluorochroman-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1,2-difluoro-3-(prop-2-yn-1-yloxy)benzene (890840-88-7) → 7,8-difluorochroman-4-one (890840-90-1)

Guidance literature:

With methanesulfonic acid; sulfuric acid; at 20 ℃;

Reference yield:

3-(2,3-difluorophenoxy)propionic acid (1310116-22-3) → 7,8-difluorochroman-4-one (890840-90-1)

Guidance literature:

With phosphorus pentaoxide; methanesulfonic acid; at 80 ℃; for 0.0833333h;

Reference yield:

2,3-difluorophenol (6418-38-8) → 7,8-difluorochroman-4-one (890840-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C / Cooling with ice

2.1: phosphorus pentaoxide; methanesulfonic acid / 0.08 h / 80 °C

With phosphorus pentaoxide; methanesulfonic acid; sodium hydride; In N,N-dimethyl-formamide;

upstream raw materials:

1,2-difluoro-3-(prop-2-yn-1-yloxy)benzene

2,3-difluorophenol

3-(2,3-difluorophenoxy)propionic acid

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