2,3-Difluorophenol

Base Information

• Chemical Name: 2,3-Difluorophenol
• CAS No.: 6418-38-8
• Molecular Formula: C6H4F2O
• Molecular Weight: 130.094
• Hs Code.: 29081000
• Mol file: 6418-38-8.mol

Synonyms:2,3-Difluoro-phenol;2,3-Dmuorophenol;Phenol, 2,3-difluoro-;

Chemical Property of 2,3-Difluorophenol

Chemical Property:

• Appearance/Colour: white crystalline low melting mass
• Vapor Pressure: 5.04mmHg at 25°C
• Melting Point: 39-42 °C(lit.)
• Refractive Index: 1.506
• Boiling Point: 141.2 °C at 760 mmHg
• PKA: 7.71±0.10(Predicted)
• Flash Point: 50.8 °C
• PSA: 20.23000
• Density: 1.351 g/cm³
• LogP: 1.67040
• Storage Temp.: Flammables area

Purity/Quality:

99% ^*data from raw suppliers

2,3-Difluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; Xi; Xn; C
• Hazard Codes: F,Xn,Xi,C
• Statements: 11-22-36/37/38-34-20/21/22
• Safety Statements: 26-45-36/37/39-16

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediates of Liquid Crystals

Technology Process of 2,3-Difluorophenol

There total 14 articles about 2,3-Difluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2,3-difluorophenyl)boronic acid (121219-16-7) → 2,3-difluorophenol (6418-38-8)

Guidance literature:

With dihydrogen peroxide; In diethyl ether; for 2.5h; Heating;

DOI:10.1039/a902351h

Reference yield: 96.49%

ortho-difluorobenzene (367-11-3) → 2,3-difluorophenol (6418-38-8)

Guidance literature:

ortho-difluorobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

With Trimethyl borate; In tetrahydrofuran; for 16h;

With dihydrogen peroxide; In tetrahydrofuran; for 3h;

Reference yield: 25.0%

1,1,2-Trifluoro-7-oxabicyclo[2.2.1]hept-4-ene (292820-75-8,292820-76-9) → 2,3-difluorophenol (6418-38-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -70 - 20 ℃; for 3.5h;

DOI:10.1016/S0022-1139(00)00250-5

upstream raw materials:

ortho-difluorobenzene

1,2,3-trifluorobenzene

(2,3-difluorophenyl)boronic acid

1,1,2-Trifluoro-7-oxabicyclo[2.2.1]hept-4-ene

Downstream raw materials:

formic acid

carbon dioxide

2,3-difluoro-L-tyrosine

1,2-difluoro-3-pentyloxybenzene

Refernces

• 1、 -. "TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF". Paragraph 00210. . Retrieved 2019/07/13.
• 2、 -. "Synthesis technology of 2,3-difluorophenol". Paragraph 0015; 0038; 0040; 0044; 0046; 0047; 0049. . Retrieved 2018/10/11.