TERT-BUTYL 2'-OXO-2',4'-DIHYDRO-1'H-SPIRO[PIPERIDINE-4,3'-QUINOLINE]-1-CARBOXYLATE

Base Information

Chemical Name:TERT-BUTYL 2'-OXO-2',4'-DIHYDRO-1'H-SPIRO[PIPERIDINE-4,3'-QUINOLINE]-1-CARBOXYLATE
CAS No.:769106-43-6
Molecular Formula:C18H24N2O3
Molecular Weight:316.39
Hs Code.:2933990090
Mol file:769106-43-6.mol

Synonyms:tert-butyl 2'-oxo-1',4'-dihydro-1H,2'H-spiro[piperidine-4,3'-quinoline]-1-carboxylate;1-Boc-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline];

Suppliers and Price of TERT-BUTYL 2'-OXO-2',4'-DIHYDRO-1'H-SPIRO[PIPERIDINE-4,3'-QUINOLINE]-1-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Boc-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline] 95+%
1g
$ 678.00

Chemenu
tert-butyl2''-oxo-1'',4''-dihydro-2''H-spiro[piperidine-4,3''-quinoline]-1-carboxylate 95%
1g
$ 641.00

American Custom Chemicals Corporation
TERT-BUTYL 2'-OXO-2',4'-DIHYDRO-1'H-SPIRO(PIPERIDINE-4,3'-QUINOLINE)-1-CARBOXYLATE 95.00%
1G
$ 1180.41

Alichem
1-Boc-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline]
1g
$ 552.00

AK Scientific
1-Boc-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline]
100mg
$ 323.60

Total 13 raw suppliers

Chemical Property of TERT-BUTYL 2'-OXO-2',4'-DIHYDRO-1'H-SPIRO[PIPERIDINE-4,3'-QUINOLINE]-1-CARBOXYLATE

Chemical Property:

Boiling Point:491.1±45.0 °C(Predicted)
PKA:14.69±0.20(Predicted)
Flash Point:250.797oC
PSA：58.64000
Density:1.19±0.1 g/cm3(Predicted)
LogP:3.27440

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline] 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 2'-OXO-2',4'-DIHYDRO-1'H-SPIRO[PIPERIDINE-4,3'-QUINOLINE]-1-CARBOXYLATE

There total 3 articles about TERT-BUTYL 2'-OXO-2',4'-DIHYDRO-1'H-SPIRO[PIPERIDINE-4,3'-QUINOLINE]-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 635713-04-1
4-(2-nitro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 769106-43-6
1-tert-butyloxycarbonyl-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline]

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 15h; under 760.051 Torr;

Reference yield:

: 635713-05-2
4-(2-Amino-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 769106-43-6
1-tert-butyloxycarbonyl-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline]

Guidance literature:: With acetic acid; at 70 ℃; for 1h;

Reference yield:

: 3958-60-9
2-nitrophenylmethyl bromide

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 769106-43-6
1-tert-butyloxycarbonyl-2'-oxo-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline]

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 18 h / -78 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; ethanol;