METHYL 4-CHLORO-3-HYDROXY-5-METHOXYTHIOPHENE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 4-CHLORO-3-HYDROXY-5-METHOXYTHIOPHENE-2-CARBOXYLATE
• CAS No.: 95201-98-2
• Molecular Formula: C₇H₇ClO₄S
• Molecular Weight: 222.649
• Hs Code.: 2934999090
• Mol file: 95201-98-2.mol

Synonyms:METHYL 4-CHLORO-3-HYDROXY-5-METHOXYTHIOPHENE-2-CARBOXYLATE;4-Chloro-3-hydroxy-5-methoxy-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 4-chloro-3-hydroxy-5-methoxy-, methyl ester

Chemical Property of METHYL 4-CHLORO-3-HYDROXY-5-METHOXYTHIOPHENE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.000329mmHg at 25°C
• Boiling Point: 310.4°C at 760 mmHg
• Flash Point: 141.5°C
• PSA: 84.00000
• Density: 1.472g/cm³
• LogP: 1.90230
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 4-chloro-3-hydroxy-5-methoxythiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of METHYL 4-CHLORO-3-HYDROXY-5-METHOXYTHIOPHENE-2-CARBOXYLATE

There total 3 articles about METHYL 4-CHLORO-3-HYDROXY-5-METHOXYTHIOPHENE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-2-methoxycarbonyl-3-oxo-2,3-dihydrothiophene (65449-58-3) → Methyl 4-chloro-3-hydroxy-5-methoxythiophene-2-carboxylate (95201-98-2)

Guidance literature:

In methanol;

Reference yield:

methyl 3-hydroxy-2-thiophenecarboxylate (5118-06-9) → Methyl 4-chloro-3-hydroxy-5-methoxythiophene-2-carboxylate (95201-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chlorosuccinimide / acetic acid / 60 °C

2: 4 h / Ambient temperature

With N-chloro-succinimide; In acetic acid;

Reference yield:

methanol (67-56-1) + 2,4-dichloro-2-methoxycarbonyl-3-oxo-2,3-dihydrothiophene (65449-58-3) → Methyl 4-chloro-3-hydroxy-5-methoxythiophene-2-carboxylate (95201-98-2)

Guidance literature:

for 4h; Yield given; Ambient temperature;

upstream raw materials:

methanol

2,4-dichloro-2-methoxycarbonyl-3-oxo-2,3-dihydrothiophene

methyl 3-hydroxy-2-thiophenecarboxylate

Downstream raw materials:

2-benzylidene-4-chloro-5-methoxythiophen-3(2H)-one

2-benzylidene-5-methoxythiophen-3(2H)-one

4-Chloro-5-methoxy-thiophen-3-one

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