Benzamide, N,2-dihydroxy-4-methyl-

Base Information

• Chemical Name: Benzamide, N,2-dihydroxy-4-methyl-
• CAS No.: 158671-29-5
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Mol file: 158671-29-5.mol

Synonyms:4-Methylsalicylhydroxamic acid;N,2-Dihydroxy-4-methylbenzamide;N-Hydroxy-2-hydroxy-4-methylbenzamide;

Chemical Property of Benzamide, N,2-dihydroxy-4-methyl-

Chemical Property:

• PKA: 8.25±0.35(Predicted)
• PSA: 69.56000
• Density: 1.332±0.06 g/cm3(Predicted)
• LogP: 1.21050
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N,2-Dihydroxy-4-methylbenzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, N,2-dihydroxy-4-methyl-

There total 3 articles about Benzamide, N,2-dihydroxy-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-hydroxy-4-methylbenzoate (4670-56-8) → N,2-dihydroxy-4-methylbenzamide (158671-29-5)

Guidance literature:

methyl 2-hydroxy-4-methylbenzoate; With sodium hydroxide; In water;

methyl 2-hydroxy-4-methylbenzoate; In 1,4-dioxane; water; at 20 ℃; for 20h;

With hydrogenchloride; In 1,4-dioxane; water; at 0 ℃; pH=5;

Reference yield:

2-hydroxy-p-toluic acid (50-85-1) → N,2-dihydroxy-4-methylbenzamide (158671-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; hexane; benzene

2: hydroxylamine; sodium hydroxide / 1,4-dioxane; water / 12 h / 20 °C

With hydroxylamine; sodium hydroxide; In 1,4-dioxane; methanol; hexane; water; benzene;

DOI:10.1021/jm201061j

Reference yield:

→ N,2-dihydroxy-4-methylbenzamide (158671-29-5)

Guidance literature:

Entspr. Methylester, NH2OH;

upstream raw materials:

methyl 2-hydroxy-4-methylbenzoate

2-hydroxy-p-toluic acid

Downstream raw materials:

6-methylbenzoxazolin-2-one

6-methyl-benzo[d]isoxazol-3-ol

3-Chlor-6-methyl-1,2-benzisoxazol

T-5224