4670-56-8

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 3534, 1980 DOI: 10.1021/ja00530a038

InChI:InChI=1/C9H10O3/c1-6-3-4-7(8(10)5-6)9(11)12-2/h3-5,10H,1-2H3

Upstream product

• 67-56-1 methanol 
• 50-85-1 2-hydroxy-p-toluic acid 
• 74590-76-4 rac-4-methoxy-4-(phenylthio)-2-butanone 
• 7664-93-9 sulfuric acid 
• 124-41-4 sodium methylate 
• 117369-83-2 methyl 5-methyl-3-oxo-6-heptenoate 
• 74590-73-1 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 586-30-1 3-hydroxy-4-methylbenzoic acid 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 74-88-4 methyl iodide 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 4478-33-5 2-Hydroxy-α,α,4-trimethylbenzyl alcohol 
• 115149-48-9 methyl 4-methyl-2-<3-(N-phthalimido)propoxy>benzoate 
• 39503-37-2 3-Formyl-2-hydroxy-4-methylbenzoesaeuremethylester 
• 83908-06-9 4-bromomethylsalicylic acid methyl ester 
• 38146-79-1 2-(2'-isobutyryloxy-4'-methylphenyl)propene 
• 81245-24-1 methyl 4-methyl-2-methoxybenzoate 
• 115-10-6 Dimethyl ether 
• 124-38-9 carbon dioxide 
• 108-39-4 3-methyl-phenol 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 951776-58-2 N,N-diethyl-2-(tert-butyldimethylsilyloxy)-4-methylbenzamide 
• 951776-59-3 C₂₁H₂₄O₅ 
• 951776-61-7 C₃₀H₃₆O₇ 
• 951776-62-8 C₄₅H₄₄O₇ 

Relevant academic research and scientific papers

Rhodium(III)-Catalyzed Oxidative Intramolecular 1,1-Oxyamination of Alkenes with Protected Amino Acids to Produce Oxazoloisoindole-2,5-diones

It has been established that an electron-deficient bis(ethoxycarbonyl)-substituted cyclopentadienyl (CpE) rhodium(III) complex catalyzes the oxidative intramolecular 1,1-oxyamination of alkenes with N-benzoyl amino acids to produce oxazoloisoindole-2,5-diones. Experimental and theoretical mechanistic studies revealed that this oxidative 1,1-oxyamination proceeds via not the aza-Wacker reaction but the formation of a rhoda(III)oxazolidine initiated by the carboxylic acid-directed N?H bond cleavage.

Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies

Alkaline phosphatases (ALPs) are membrane bound metalloenzymes, distributed all over the body. Recent studies have revealed that by targeting ALPs can lead towards the treatment of many deadliest diseases including cardiac, cancerous and brain diseases. Thioureas and their derivatives are of considerable significance and are privileged scaffolds in medicinal chemistry. They show a wide range of pharmacological activities such as antibacterial, antiparasitic, anti-inflammatory and antioxidants etc. On the other hand, salicylic acid and its derivatives are known for its broad spectrum of activities. The work presented comprises of synthesis of N-acyl-N'-aryl substituted bisthioureas of pimelic acid (1–7) and 3,5-dimethyl pyrazole (11), 1-aroyl-3-aryl thiourea (12) and 1,3,4-oxadiazole (13) derivatives of 4-methyl salicylic acid. Structures of all the synthesized compounds were characterized by FT-IR and 1H NMR spectroscopic analysis. Synthesized compounds were evaluated for their alkaline phosphatases inhibition potential and exhibited high potency as well as selectivity towards h-TNAP and h-IAP. Compound 7 and 12 which were the bisthiourea derivative of pimmelic acid and thiourea derivative of 4-methyl salicylic acid, respectively, showed excellent selectivity against h-TNAP and h-IAP, respectively.

Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

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POLYCYCLIC AMIDES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

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π-Expanded Thioxanthones – Engineering the Triplet Level of Thioxanthone Sensitizers for Lanthanide-Based Luminescent Probes with Visible Excitation

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Microwave-Assisted Synthesis of Benzofuran-3(2H)-ones

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C-GLUCOSIDE DERIVATIVE CONTAINING FUSED PHENYL RING OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

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Antifungal activity of cinnamic acid and benzoic acid esters against Candida albicans strains

Candida albicans is an important opportunistic fungal pathogen capable of provoking infection in humans. In the present study, we evaluated the antifungal effect of 23 ester derivatives of the cinnamic and benzoic acids against 3 C. albicans strains (ATCC-76645, LM-106 and LM-23), as well as discuss their Structure–Activity Relationship (SAR). The antifungal assay results revealed that the screened compounds exhibited different levels of activity depending on structural variation. Among the ester analogues, methyl caffeate (5) and methyl 2-nitrocinnamate (10) were the analogues that presented the best antifungal effect against all C. albicans strains, presenting the same MIC values (MIC?=?128?μg/mL), followed by methyl biphenyl-2-carboxylate (21) (MIC?=?128, 128 and 256?μg/mL for C. albicans LM-106, LM-23, and ATCC-76645, respectively). Our results suggest that certain molecular characteristics are important for the antifungal action.

Synthesis technology of C-Fos/AP-1 inhibitor

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