L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI)

Base Information

• Chemical Name: L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI)
• CAS No.: 914361-45-8
• Molecular Formula: C23H20F2N5O5PS.C6H14N2O2.C2H6O
• Molecular Weight: 739.737
• Mol file: 914361-45-8.mol

Synonyms:E-1224 L-lysine ethanolate;BMS-379224 L-lysine ethanolate;Fosravuconazole L-lysine ethanolate;L-Lysine, coMpd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-Methyl-2-[(phosphonooxy)Methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI)

Chemical Property of L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI)

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Fosravuconazole(L-lysineethanolate) 96.30% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI)

There total 1 articles about L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethanol (64-17-5) + L-lysine (56-87-1,3506-25-0) + di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate (351227-63-9) → lysine [{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)-1-propyl}oxy]methyl dihydrogenphosphate ethanol (1/1/1) (914361-45-8)

Guidance literature:

di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate; With hydrogenchloride; water; In methanol; at -20 - 0 ℃; for 5.23h;

With potassium phosphate; dipotassium hydrogenphosphate; disodium hydrogenphosphate; In methanol; water; ethyl acetate;

ethanol; L-lysine; With hydrogenchloride; acetic acid; more than 3 stages; Product distribution / selectivity;

upstream raw materials:

ethanol

L-lysine

di-tert-butyl-[{(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl}-oxy]methyl phosphate