4-Pyridazinemethanol

Base Information

• Chemical Name: 4-Pyridazinemethanol
• CAS No.: 50901-43-4
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 2933990090
• European Community (EC) Number: 838-082-2
• DSSTox Substance ID: DTXSID70536583
• Wikidata: Q82411303
• Mol file: 50901-43-4.mol

Synonyms:4-Pyridazinemethanol;pyridazin-4-ylmethanol;50901-43-4;(Pyridazin-4-yl)methanol;MFCD06227446;4-Hydroxymethylpyridazin;4-hydroxymethylpyridazine;SCHEMBL501882;DTXSID70536583;AKOS006292565;PB26178;AS-33429;SY111189;AM20100249;CS-0053747;EN300-200458;A828346;J-515980

Chemical Property of 4-Pyridazinemethanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 325.731°C at 760 mmHg
• PKA: 13.24±0.10(Predicted)
• Flash Point: 150.797°C
• PSA: 46.01000
• Density: 1.228g/cm³
• LogP: -0.03110
• Storage Temp.: 2-8°C
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 110.048012819
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

pyridazin-4-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=NC=C1CO

Technology Process of 4-Pyridazinemethanol

There total 7 articles about 4-Pyridazinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.5%

trans-4-styrylpyridazine (35782-28-6) → 4-hydroxymethylpyridazine (50901-43-4)

Guidance literature:

trans-4-styrylpyridazine; With oxygen; In methanol; at -10 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 33.0%

methyl pyridazine-4-carboxylate (34231-77-1) → 4-hydroxymethylpyridazine (50901-43-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1h;

DOI:10.1016/j.bmcl.2019.126681

Reference yield: 20.0%

ethyl pyridazine-4-carboxylate (39123-39-2) → 4-hydroxymethylpyridazine (50901-43-4)

Guidance literature:

ethyl pyridazine-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sodium hydroxide; water; In tetrahydrofuran; at 0 ℃;

upstream raw materials:

ethyl pyridazine-4-carboxylate

4-styrylpyridazine

4-methylpyridazine

trans-4-styrylpyridazine

Downstream raw materials:

5-(2-n-propoxyphenyl)-3-n-propyl-2-(pyridazin-4-yl)methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

5--8-nitronaphthalene-1-carbonitrile

methyl(pyridazinylmethyl)amine