4-Styrylpyridazine

Base Information

• Chemical Name: 4-Styrylpyridazine
• CAS No.: 39816-19-8
• Molecular Formula: C12H10N2
• Molecular Weight: 182.225
• NSC Number: 283144
• Nikkaji Number: J2.342.932B
• Mol file: 39816-19-8.mol

Synonyms:4-Styrylpyridazine;39816-19-8;4 Styrylpyridazine;4Styrylpyridazine;4-[(E)-2-Phenylethenyl]pyridazine;(E)-4-styrylpyridazine;NSC283144;SCHEMBL6332506;Pyridazine,4-(2-phenylethenyl)-;WHUUTUUXTSPPDS-VOTSOKGWSA-N;AKOS006229070;4-[(E)-2-Phenylethenyl]pyridazine #;NSC-283144;F89276;35782-28-6

Chemical Property of 4-Styrylpyridazine

Chemical Property:

• Vapor Pressure: 3.57E-05mmHg at 25°C
• Refractive Index: 1.675
• Boiling Point: 364.2 °C at 760 mmHg
• Flash Point: 168.9 °C
• PSA: 25.78000
• Density: 1.145 g/cm³
• LogP: 2.64700
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 182.084398327
• Heavy Atom Count: 14
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

4 STYRYLPYRIDAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=CC2=CN=NC=C2
• Isomeric SMILES: C1=CC=C(C=C1)/C=C/C2=CN=NC=C2

Technology Process of 4-Styrylpyridazine

There total 1 articles about 4-Styrylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-methylpyridazine (1120-88-3) + benzaldehyde (100-52-7) → 4-styrylpyridazine (39816-19-8)

Guidance literature:

With zinc(II) chloride; at 160 ℃; for 5h;

Reference yield: 82.0%

4-styrylpyridazine (39816-19-8) → pyridazine-4-carbaldehyde (50901-42-3)

Guidance literature:

4-styrylpyridazine; With osmium(VIII) oxide; In 1,4-dioxane; water; tert-butyl alcohol;

With sodium periodate; for 6h;

Reference yield: 26.0%

4-styrylpyridazine (39816-19-8) + trimethylsilyl cyanide (7677-24-9) → (E)-5-styrylpyridazine-3-carbonitrile + C13H9N3

Guidance literature:

4-styrylpyridazine; trimethylsilyl cyanide; With aluminum (III) chloride; p-toluenesulfonyl chloride; In tetrahydrofuran; at 10 ℃; for 49h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 2h; Overall yield = 71 %; regioselective reaction;

DOI:10.1016/j.tetlet.2016.05.037

upstream raw materials:

4-methylpyridazine

benzaldehyde

Downstream raw materials:

pyridazine-4-carbaldehyde

4-hydroxymethylpyridazine