3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)
• CAS No.: 951163-66-9
• Molecular Formula: C18H17BFNO8
• Molecular Weight: 405.144
• Mol file: 951163-66-9.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)

There total 5 articles about 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid (221221-16-5) → C18H17BFNO8 (951163-66-9)

Guidance literature:

acetic anhydride; With boron trioxide; In acetic acid; for 2h; Heating / reflux;

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid; In acetic acid; for 6h; Heating / reflux;

Reference yield: 86.4%

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid (221221-16-5) + acetic anhydride (108-24-7) + boron trioxide (1103242-32-5) → C18H17BFNO8 (951163-66-9)

Guidance literature:

acetic anhydride; boron trioxide; With acetic acid; for 2h; Reflux;

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid; With tert-butyl methyl ether; In toluene; for 6h; Reflux;

Reference yield: 86.4%

boron trioxide + 1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid (221221-16-5) + acetic acid (64-19-7,77671-22-8) → C18H17BFNO8 (951163-66-9)

Guidance literature:

boron trioxide; acetic anhydride; acetic acid; for 2h; Heating / reflux;

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid; for 6h; Heating / reflux;

upstream raw materials:

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid

triacetoxyborane

acetic acid

acetic anhydride

Downstream raw materials:

1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid

Refernces

• 1、 -. "ANTIBIOTIC DRUG". Page/Page column 9. . Retrieved 2010/04/03.
• 2、 -. "Hydride reduction process for preparing quinolone intermediates". Page/Page column 7. . Retrieved 2008/06/13.