221221-16-5

Basic information

• Product Name: 1-cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: 1-cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;1-Cyclopropyl-7-fluoro-1,4-dihydro-8-Methoxy-4-oxo-3-quinolinecarboxylic Acid
• CAS NO: 221221-16-5
• Molecular Formula: C₁₄H₁₂FNO₄
• Molecular Weight: 277.25
• Mol File: 221221-16-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 463.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.519
• Storage Temp.: 2-8°C
• PKA: 6.44±0.50(Predicted)
• CAS DataBase Reference: 1-cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(221221-16-5)
• EPA Substance Registry System: 1-cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(221221-16-5)

Safety Data

• Hazardous Substances Data: 221221-16-5(Hazardous Substances Data)

Usage

Uses

1-Cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic Acid can be used as a reactant to prepare 7-amino alkylidenyl-heterocyclic quinolones as antibacterial agents.

Upstream product

• 221221-15-4 ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate 
• 951163-66-9 C₁₈H₁₇BFNO₈ 
• 221221-11-0 2,4-difluoro-3-methoxybenzoyl chloride 
• 178974-97-5 2,4-difluoro-3-methoxy-benzoic acid 
• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 28177-48-2 2,6-difluorophenol 
• 162101-25-9 2,6-difluorophenylboronic acid 
• 372-18-9 1,3-Difluorobenzene 

Downstream Products

• 926279-65-4 1-cyclopropyl-7-fluoro-8-hydroxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 951163-66-9 C₁₈H₁₇BFNO₈ 

Relevant articles and documents

A method for preparing [...] chelate compound

The invention discloses a method for directly preparing a nemonoxacin chelate from nemonoxacin cyclization ester. According to the existing method, a reaction step is longer, and an amount of aftertreatment processes is larger, thus obviously prolonging the whole time of preparing nemonoxacin; and in addition, industrial production and environmental protection are not facilitated. The method comprises the following steps of: based on carboxylic acid anhydride or a mixed solvent of the carboxylic acid anhydride and carboxylic acid as a reaction solvent, adding boric acid or boric anhydride to carry out reaction; and adding the nemonoxacin cyclization ester into an obtained reaction solution to carry out chelation reaction, thus obtaining the nemonoxacin chelate. According to the preparation method, only one chelation reaction step exists, and a hydrolysis reaction process and complex aftertreatment operations thereof such as filtering and drying are saved, thus greatly shortening the whole time of preparing the nemonoxacin, and facilitating industrial production; and meanwhile, by avoiding the using of reagents such as concentrated hydrochloric acid and ethanol, the preparation method is economic and environment-friendly.

Novel Antibacterial Compounds

The invention relates to novel chimeric antibiotics of formula I wherein R1 is CH2NHCOR5, heteroarylmethyl, heteroaryloxymethyl or heteroarylaminomethyl;R2 is H, OH, OSO3H, OPO3H2, OCH2OPO3H2, OCOCH2CH2COOH, OCOR6;R3 is H or halogen;R4 is (C1-C3)alkyl, (C1-C3)haloalkyl or cycloalkyl;R5 is alkyl or haloalkyl; andR6 is the residue of a naturally occurring amino acid or of dimethylaminoglycine. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).

Coupling process for preparing quinolone intermediates

Process for making 7-cycloamino-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids. Borate ester compounds suitable for use in such process.