3-Methoxy-6-(4-methoxyphenyl)pyridazine

Base Information

• Chemical Name: 3-Methoxy-6-(4-methoxyphenyl)pyridazine
• CAS No.: 242802-84-2
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90572847
• Nikkaji Number: J2.315.197I
• Wikidata: Q82461342
• Mol file: 242802-84-2.mol

Synonyms:3-methoxy-6-(4-methoxyphenyl)pyridazine;242802-84-2;SCHEMBL25591566;DTXSID90572847;J-512774

Chemical Property of 3-Methoxy-6-(4-methoxyphenyl)pyridazine

Chemical Property:

• PSA: 44.24000
• LogP: 2.16080
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 216.089877630
• Heavy Atom Count: 16
• Complexity: 205

Purity/Quality:

98%min ^*data from raw suppliers

3-Methoxy-6-(4-methoxyphenyl)pyridazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NN=C(C=C2)OC

Technology Process of 3-Methoxy-6-(4-methoxyphenyl)pyridazine

There total 7 articles about 3-Methoxy-6-(4-methoxyphenyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-chloro-6-methoxypyridazine (1722-10-7) + 4-methoxyphenylboronic acid (5720-07-0) → 3-methoxy-6-(4-methoxyphenyl)pyridazine (242802-84-2)

Guidance literature:

With potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In water; toluene; for 12h; Heating;

DOI:10.1021/ol060268g

Reference yield: 87.0%

3-chloro-6-methoxypyridazine (1722-10-7) + 4-chloromethoxybenzene (623-12-1) → 3-methoxy-6-(4-methoxyphenyl)pyridazine (242802-84-2)

Guidance literature:

4-chloromethoxybenzene; With tetrahydroxydiboron; dicyclohexyl(2',4',6'-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane; Pd(Cy*Phine)₂Cl₂ ; potassium acetate; In butan-1-ol; at 80 ℃; Glovebox; Inert atmosphere; Schlenk technique; Sealed tube;

3-chloro-6-methoxypyridazine; With potassium carbonate; In water; butan-1-ol; at 80 ℃; for 1.5h; Glovebox; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201600708

Reference yield: 82.0%

1-bromo-4-methoxy-benzene (104-92-7) + sodium 6-methoxypyridazine-3-sulfinate → 3-methoxy-6-(4-methoxyphenyl)pyridazine (242802-84-2)

Guidance literature:

With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02944

upstream raw materials:

3-chloro-6-methoxypyridazine

4-methoxyphenylboronic acid

para-iodoanisole

4-chloromethoxybenzene

Downstream raw materials:

3-methoxy-6-(4-methoxyphenyl)-4-pyridazinylboronic acid