2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1218791-09-3
• Molecular Formula: C12H15BFNO4
• Molecular Weight: 267.065
• Hs Code.: 2934999090
• Mol file: 1218791-09-3.mol

Synonyms:2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-Fluoro-3-nitrobenzeneboronic acid, pinacol ester 95%;4-Fluoro-3-nitrophenylboronic acid, pinacol ester

Chemical Property of 2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• Boiling Point: 355.4±32.0 °C(Predicted)
• PSA: 64.28000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 2.55630
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

97% ^*data from raw suppliers

4-Fluoro-3-nitrophenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Fluoro-3-nitrobenzeneboronic acid is generally used as a intermediate in pharmaceutical and chemical research.

Technology Process of 2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 1 articles about 2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) + bis(pinacol)diborane (73183-34-3) → 2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1218791-09-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 108 ℃; for 12h; Inert atmosphere;

Reference yield: 100.0%

2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1218791-09-3) → 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1003575-43-6)

Guidance literature:

With hydrogen; 1% Pd/C; In ethyl acetate; for 2h; under 2585.81 Torr; Inert atmosphere;

Reference yield:

2-(4-fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1218791-09-3) + 2-bromopyrimidine (4595-60-2) → C10H6FN3O2

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 7.25h;

upstream raw materials:

4-Bromo-1-fluoro-2-nitrobenzene

bis(pinacol)diborane

Downstream raw materials:

2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline