2-Propoxypyridine-5-boronic acid

Base Information

• Chemical Name: 2-Propoxypyridine-5-boronic acid
• CAS No.: 1150114-50-3
• Molecular Formula: C₈H₁₂BNO₃
• Molecular Weight: 180.999
• Hs Code.: 2933399090
• Mol file: 1150114-50-3.mol

Synonyms:10-phenylantrhacen-9-yl boronic acid

Chemical Property of 2-Propoxypyridine-5-boronic acid

Chemical Property:

• Appearance/Colour: off-white solid
• Boiling Point: 333.5±52.0 °C(Predicted)
• PKA: 7.02±0.17(Predicted)
• PSA: 62.58000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: -0.44980
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Propoxypyridine-5-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propoxypyridine-5-boronic acid

There total 3 articles about 2-Propoxypyridine-5-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H24BNO3 → 6-propoxypyridine-3-boronic acid (1150114-50-3)

Guidance literature:

C₁₄H₂₄BNO₃; With sodium hydroxide; In water; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.1016/j.ejmech.2015.02.056

Reference yield:

5-bromo-2-fluoropyridine (766-11-0) → 6-propoxypyridine-3-boronic acid (1150114-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Reflux

1.2: 12 h / Reflux

2.1: n-butyllithium / diethyl ether; tetrahydrofuran / 1 h / -78 °C

2.2: 1 h

3.1: sodium hydroxide / water / 20 °C

With n-butyllithium; sodium hydride; sodium hydroxide; In tetrahydrofuran; diethyl ether; water;

DOI:10.1016/j.ejmech.2015.02.056

Reference yield:

5-bromo-2-propoxy-pyridine (850142-79-9) → 6-propoxypyridine-3-boronic acid (1150114-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h

2.1: sodium hydroxide / water / 20 °C

With n-butyllithium; sodium hydroxide; In tetrahydrofuran; diethyl ether; water;

DOI:10.1016/j.ejmech.2015.02.056

upstream raw materials:

5-bromo-2-fluoropyridine

5-bromo-2-propoxy-pyridine

Refernces