850142-79-9

Basic information

• Product Name: 5-Bromo-2-propoxypyridine
• Synonyms: 5-Bromo-2-propoxypyridine
• CAS NO: 850142-79-9
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.08
• Product Categories: blocks;Bromides;Pyridines
• Mol File: 850142-79-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 235.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.386±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.76±0.22(Predicted)
• CAS DataBase Reference: 5-Bromo-2-propoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-propoxypyridine(850142-79-9)
• EPA Substance Registry System: 5-Bromo-2-propoxypyridine(850142-79-9)

Safety Data

• Hazardous Substances Data: 850142-79-9(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-propoxypyridine is a chemical compound with the molecular formula C8H8BrNO. It is a pyridine derivative with a bromine atom at the 5th position and a propoxy group attached to the 2nd position of the pyridine ring. 5-Bromo-2-propoxypyridine is often used as a building block in organic synthesis for the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its reactivity and versatility in various chemical reactions, making it a valuable intermediate in the production of diverse compounds. Additionally, 5-Bromo-2-propoxypyridine is commonly used in research and development laboratories as a key component in the synthesis of new and complex molecules.

Upstream product

• 71-23-8 propan-1-ol 
• 223463-13-6 2-iodo-5-bromopyridine 
• 766-11-0 5-bromo-2-fluoropyridine 
• 53939-30-3 5-bromo-2-chloropyridine 
• 39856-50-3 5-bromo2-nitropyridine 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 1300728-38-4 N-phenyl-6-propoxypyridin-3-amine 
• 1300728-30-6 N-(2-chlorophenyl)-6-propoxypyridin-3-amine 
• 1417655-93-6 C₂₀H₂₄N₂O₃ 
• 1150114-50-3 6-propoxypyridine-3-boronic acid 

Relevant articles and documents

Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer

We report a general protocol for the direct C-H etherification of N-heteroarenes. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alcohol substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcohols with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.

Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: Study of 6-substituted pyridine-3-boronic acid derivatives

In response to the extensive use of antibiotics, bacteria have evolved numerous mechanisms of defense against antimicrobial agents. Among them, extrusion of the antimicrobial agents outside the bacterial cell through efflux pumps is a major cause of concern. At first limited to one or few structurally-related antibiotics, bacterial resistance have then progressed towards cross-resistance between different classes of antibiotics, leading to multidrug-resistant microorganisms. Emergence of these pathogens requires development of novel therapeutic strategies and inhibition of efflux pumps appears to be a promising strategy that could restore the potency of existing antibiotics. NorA is the most studied chromosomal efflux pump of Staphylococcus aureus; it is known to be implied in resistance of Methicillin-resistant S. aureus (MRSA) strains against a wide range of unrelated substrates, including hydrophilic fluoroquinolones. Starting from 6-benzyloxypyridine-3-boronic acid I that we previously identified as a potential inhibitor of the NorA efflux pump against the NorA-overexpressing S. aureus 1199B strain (SA1199B), we describe here the synthesis and biological evaluation of a series of 6-(aryl)alkoxypyridine-3-boronic acids. 6-(3-Phenylpropoxy)pyridine-3-boronic acid 3i and 6-(4-phenylbutoxy)pyridine-3-boronic acid 3j were found to potentiate ciprofloxacin activity by a 4-fold increase compared to the parent compound I. In addition, it has been shown that both compounds promote Ethidium Bromide (EtBr) accumulation in SA1199B, thus corroborating their potential mode of action as NorA inhibitors.

FUSED LACTAM COMPOUNDS

This invention provides a compound the formula (I), wherein R1 represents an aryl group having from 6 to 10 ring carbon atoms etc.; R2 represents a hydrogen atom etc., n epresents 0, 1 or 2; said heteroaryl group is unsubstituted or