6-Methoxy-2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine

Base Information

• Chemical Name: 6-Methoxy-2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine
• CAS No.: 1080028-73-4
• Molecular Formula: C₁₃H₂₀BNO₃
• Molecular Weight: 249.118
• Hs Code.: 2934999090
• Mol file: 1080028-73-4.mol

Synonyms:6-Methoxy-2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine;6-Methoxy-2-Methylpyridine-3-boronic acid pinacol ester, 96%

Chemical Property of 6-Methoxy-2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine

Chemical Property:

• Boiling Point: 335.2±42.0 °C(Predicted)
• PKA: 4.11±0.12(Predicted)
• PSA: 40.58000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 1.69780
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

b6-Methoxy-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methoxy-2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine

There total 1 articles about 6-Methoxy-2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-bromo-6-methoxy-2-methylpyridine (126717-59-7) + bis(pinacol)diborane (73183-34-3) → 6-methoxy-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1080028-73-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 95 ℃; for 16h; Sealed tube;

Reference yield: 72.0%

6-methoxy-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1080028-73-4) + N-(2-bromophenyl)-2,2-dimethylpropanamide (65854-92-4) → N-(2-(6-methoxy-2-methylpyridin-3-yl)phenyl)pivalamide (1440427-25-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 12h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201209591

Reference yield:

6-methoxy-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1080028-73-4) + o-cyanobromobenzene (2042-37-7) → 2-(6-methoxy-2-methylpyridin-3-yl)benzonitrile

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In 1,4-dioxane; at 100 ℃; for 12h;

upstream raw materials:

3-bromo-6-methoxy-2-methylpyridine

bis(pinacol)diborane

Downstream raw materials:

N-(2-(6-methoxy-2-methylpyridin-3-yl)phenyl)pivalamide

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