2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE

Base Information

• Chemical Name: 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE
• CAS No.: 1262414-96-9
• Molecular Formula: C10H13FO
• Molecular Weight: 168.21
• Mol file: 1262414-96-9.mol

Synonyms:2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE;2-Fluoro-4-methoxy-1-isopropylbenzene;2-fluoro-isopropyl-4-Methoxybenzene;Benzene, 2-fluoro-4-Methoxy-1-(1-Methylethyl)-

Chemical Property of 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE

Chemical Property:

• Boiling Point: 190℃
• Flash Point: 67℃
• PSA: 9.23000
• Density: 1.002
• LogP: 2.95770
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

2-Fluoro-1-isopropyl-4-methoxybenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE

There total 4 articles about 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-fluoro-4-methoxyphenyl)-2-isopropanol (96826-25-4) → 2-(2-fluoro-4-methoxyphenyl)isopropane (1262414-96-9)

Guidance literature:

With diphenyl sulfide; 5%-palladium/activated carbon; hydrogen; trifluoroacetic acid; In Isopropyl acetate; at 60 ℃; for 12h; under 3345.86 Torr; Inert atmosphere;

Reference yield: 90.65%

2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene (875446-55-2) → 2-(2-fluoro-4-methoxyphenyl)isopropane (1262414-96-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 30 ℃; for 6.16667h; under 750.075 Torr; Solvent;

Reference yield:

1-(2-fluoro-4-methoxyphenyl)-1-ethanone (74457-86-6) → 2-(2-fluoro-4-methoxyphenyl)isopropane (1262414-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 25 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm200484c

upstream raw materials:

2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene

2-(2-fluoro-4-methoxyphenyl)-2-isopropanol

1-(2-fluoro-4-methoxyphenyl)-1-ethanone

1-bromo-2-fluoro-4-methoxybenzene

Downstream raw materials:

(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol

(+)-(5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one

(-)-(5S)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one

(+)-(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,5-dimethyl-1,3-oxazolidin-2-one

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