(R)-2-(N-Cbz-3-pyrrolidinyl)-2-propanol

Base Information

• Chemical Name: (R)-2-(N-Cbz-3-pyrrolidinyl)-2-propanol
• CAS No.: 402927-96-2
• Molecular Formula: C14H20N2O4S
• Molecular Weight: 312.39
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID10849442
• Wikidata: Q82842305
• Mol file: 402927-96-2.mol

Synonyms:(R)-2-(N-Cbz-3-pyrrolidinyl)-2-propanol;1417789-56-0;benzyl (3R)-3-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate;(R)-Benzyl 3-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate;MFCD18071038;DTXSID10849442;AC2216;AS-74084;CS-0079029;1-Pyrrolidinecarboxylic acid, 3-(1-hydroxy-1-methylethyl)-, phenylmethyl ester, (3R)-

Chemical Property of (R)-2-(N-Cbz-3-pyrrolidinyl)-2-propanol

Chemical Property:

• PSA: 84.09000
• LogP: 2.74640
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 263.15214353
• Heavy Atom Count: 19
• Complexity: 311

Purity/Quality:

97% ^*data from raw suppliers

4-(Cbz-amino)-1-(methylsulfonyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C1CCN(C1)C(=O)OCC2=CC=CC=C2)O
• Isomeric SMILES: CC(C)([C@@H]1CCN(C1)C(=O)OCC2=CC=CC=C2)O

Technology Process of (R)-2-(N-Cbz-3-pyrrolidinyl)-2-propanol

There total 1 articles about (R)-2-(N-Cbz-3-pyrrolidinyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + piperidin-4-ylcarbamic acid benzyl ester (182223-54-7) → C14H20N2O4S (402927-96-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

C14H20N2O4S (402927-96-2) → 4-amino-1-methanesulfonylpiperidine (402927-97-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 15h;

upstream raw materials:

methanesulfonyl chloride

piperidin-4-ylcarbamic acid benzyl ester

Downstream raw materials:

4-amino-1-methanesulfonylpiperidine