6-(2-Furyl)picolinaldehyde

Base Information

• Chemical Name: 6-(2-Furyl)picolinaldehyde
• CAS No.: 208110-88-7
• Molecular Formula: C10H7NO2
• Molecular Weight: 173.171
• Hs Code.: 2934999090
• Mol file: 208110-88-7.mol

Synonyms:6-(2-Furyl)picolinaldehyde

Chemical Property of 6-(2-Furyl)picolinaldehyde

Chemical Property:

• PSA: 43.10000
• LogP: 2.15410

Purity/Quality:

98%min ^*data from raw suppliers

6-(2-Furyl)picolinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(2-Furyl)picolinaldehyde

There total 8 articles about 6-(2-Furyl)picolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

(6-(furan-2-yl)pyridin-2-yl)methanol (208110-87-6) → 6-(furan-2-yl)pyridine-2-carboxaldehyde (208110-88-7)

Guidance literature:

With manganese dioxide; In chloroform;

Reference yield: 64.4%

fur-2-ylboronic acid (13331-23-2) + 6-bromo-2-pyridinecarbaldehyde (34160-40-2) → 6-(furan-2-yl)pyridine-2-carboxaldehyde (208110-88-7)

Guidance literature:

fur-2-ylboronic acid; 6-bromo-2-pyridinecarbaldehyde; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 85 ℃;

With sodium hydrogencarbonate; In water;

Reference yield:

6-chloro-2-pyridinemethanol (33674-97-4) → 6-(furan-2-yl)pyridine-2-carboxaldehyde (208110-88-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 76.6 percent / DIEA / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 1.5 h, 2.) DMF, 40 deg C, 12 h

3: 76.8 percent / H₂, HCl / Raney Ni / ethanol / 1.5 h / Ambient temperature

4: 75 percent / DMAP / pyridine / 2 h / 0 °C

5: Tl₂CO₃, Pd6H₅)3>4 / benzene / 23 h / Ambient temperature

6: nBuNF, HMPA, 4 Angstroem molecular sieves / tetrahydrofuran / 8 h / Ambient temperature

7: MnO₂ / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Ti₂CO₃; 4 A molecular sieve; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; nickel; In tetrahydrofuran; pyridine; ethanol; dichloromethane; benzene;

DOI:10.1021/jm9804329

upstream raw materials:

(6-(furan-2-yl)pyridin-2-yl)methanol

6-chloro-2-pyridinemethanol

2-chloro-6-<2-(trimethylsilanyl)ethoxymethoxymethyl>pyridine

2-hydroxy-6-<2-(trimethylsilanyl)ethoxymethoxymethyl>pyridine

Refernces

• 1、 -. "Pyridin-2-yl-methylamine derivatives, method of preparing and application as medicine". . . Retrieved 2008/06/13.