(6-Chloro-2-pyridinyl)methanol

Base Information

• Chemical Name: (6-Chloro-2-pyridinyl)methanol
• CAS No.: 33674-97-4
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.573
• Hs Code.: 2933399090
• Mol file: 33674-97-4.mol

Synonyms:(6-Chloropyridin-2-yl)methanol;2-Chloro-6-(hydroxymethyl)pyridine;6-Chloro-2-pyridinemethanol;6-Chloro-2-pyridylmethanol;（6-chloro-2-pyridinyl）methanol;

Chemical Property of (6-Chloro-2-pyridinyl)methanol

Chemical Property:

• Vapor Pressure: 0.0105mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 251.8 °C at 760 mmHg
• PKA: 13.12±0.10(Predicted)
• Flash Point: 106.1 °C
• PSA: 33.12000
• Density: 1.324 g/cm³
• LogP: 1.22730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(6-Chloro-2-pyridinyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-Chloro-2-pyridinyl)methanol

There total 2 articles about (6-Chloro-2-pyridinyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + N-methoxy-2-chloropyridinium methylsulfate (116570-79-7) → 6-chloro-2-pyridinemethanol (33674-97-4) + (2-chloropyridin-4-yl)methanol (100704-10-7)

Guidance literature:

With fac-tris[2-phenylpyridinato-C²,N]iridium(III); sodium hydrogencarbonate; In acetonitrile; for 2h; Overall yield = 71 percent; Irradiation;

DOI:10.1021/acscatal.0c03726

Reference yield:

→ 6-chloro-2-pyridinemethanol (33674-97-4) + 6-chloropyridine-2-carboxaldehyde (54087-03-5)

Guidance literature:

Reference yield: 76.0%

6-chloro-2-pyridinemethanol (33674-97-4) → 6-chloropyridine-2-carboxaldehyde (54087-03-5)

Guidance literature:

With phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; for 1.5h; Ambient temperature;

DOI:10.1248/cpb.38.2446

upstream raw materials:

methanol

N-methoxy-2-chloropyridinium methylsulfate

Downstream raw materials:

6-chloropyridine-2-carboxaldehyde

2-Chloro-6-(dichloromethyl)-pyridine

6-chloro-2-phenylthiomethylpyridine

α-fluoro-6-(4-phenylpiperazinyl)-2-picoline N-oxide

Refernces

• 1、 -. "Substituted 2-acylpyridine-α-(N)-hetarlyhydrazones and medicaments containing the same". . . Retrieved 2008/06/13.