33674-97-4

Basic information

• Product Name: (6-Chloro-2-pyridinyl)methanol
• Synonyms: CHEMPACIFIC 38159;(6-CHLORO-PYRIDIN-2-YL)-METHANOL;(6-Chloro-2-pyridinyl)methanol;2-Chloro-6-(Hydroxymethyl)Pyridine;6-Chloro-2-pyridinemethanol;2-Chloropyridine-6-Methanol
• CAS NO: 33674-97-4
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: -0
• Mol File: 33674-97-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 251.8 °C at 760 mmHg
• Flash Point: 106.1 °C
• Appearance: /
• Density: 1.324 g/cm³
• Vapor Pressure: 0.0105mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.12±0.10(Predicted)
• CAS DataBase Reference: (6-Chloro-2-pyridinyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (6-Chloro-2-pyridinyl)methanol(33674-97-4)
• EPA Substance Registry System: (6-Chloro-2-pyridinyl)methanol(33674-97-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 33674-97-4(Hazardous Substances Data)

Usage

General Description

(6-Chloro-2-pyridinyl)methanol is a chemical compound with a molecular formula of C6H6ClNO. It is a white solid that is soluble in water and has a boiling point of 245 degrees Celsius. This chemical is used in the synthesis of pharmaceuticals and agrochemicals and has bactericidal and fungicidal properties. It is also used as an intermediate in the production of other chemicals and has potential applications in the field of medicine and agriculture. However, it should be handled with care as it may be harmful if ingested, inhaled, or absorbed through the skin, and can cause irritation to the respiratory system and skin. Proper safety measures should be taken when handling this chemical.

InChI:InChI=1/C6H6ClNO/c7-6-3-1-2-5(4-9)8-6/h1-3,9H,4H2

Upstream product

• 67-56-1 methanol 
• 116570-79-7 N-methoxy-2-chloropyridinium methylsulfate 

Downstream Products

• 208111-00-6 6-(thien-2-yl)pyridine-2-carboxyaldehyde 
• 208110-88-7 6-(furan-2-yl)pyridine-2-carboxaldehyde 
• 208110-94-5 2-(benzyloxy)-6-<2-(trimethylsilanyl)ethoxymethoxymethyl>pyridine 
• 63763-79-1 2-chloro-6-(bromomethyl)pyridine 
• 105243-77-4 (6-(methylamino)pyrid-2-yl)methanol 
• 933734-79-3 C₇H₉ClN₂ 
• 75279-60-6 2-(6-chloropyridin-2-yl)acetonitrile 
• 108337-79-7 2,6-dimethyl-4-(6-chloro-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 253686-25-8 α-fluoro-6-(4-phenylpiperazinyl)-2-picoline N-oxide 
• 460720-22-3 6-chloro-2-phenylthiomethylpyridine 
• 78152-53-1 2-Chloro-6-(dichloromethyl)-pyridine 
• 54087-03-5 6-chloropyridine-2-carboxaldehyde 

Relevant articles and documents

Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms

Considering the synthetic relevance of heteroarenes in various areas ranging from organic synthesis to medicinal chemistry, developing practically simple methodologies to access functionalized heteroarenes is of a significant value. Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation. The synthetic importance of the developed reactions is demonstrated by the synthesis of biologically relevant compounds. Electron paramagnetic resonance spectroscopy, quantum yield measurements, and density-functional theory calculations allowed us to understand reaction mechanisms of both photocatalytic reactions.