Methyl 2-(piperidin-3-yl)acetate hydrochloride

Base Information

• Chemical Name: Methyl 2-(piperidin-3-yl)acetate hydrochloride
• CAS No.: 247259-31-0
• Molecular Formula: C8H15NO2.ClH
• Molecular Weight: 193.671
• Hs Code.: 2933399090
• Mol file: 247259-31-0.mol

Synonyms:3-Piperidine acetate methyl ester hydrochloride;3-Piperidine acetate methyl ester-HCl;RW1089;

Chemical Property of Methyl 2-(piperidin-3-yl)acetate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.67990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl3-PiperidylacetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-Piperidylacetate is an analog of Methylphenidate (M325880, HCl salt), a CNS stimulant.

Technology Process of Methyl 2-(piperidin-3-yl)acetate hydrochloride

There total 2 articles about Methyl 2-(piperidin-3-yl)acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-pyridylacetate hydrochloride (69966-42-3) → methyl 3-piperidylacetate hydrochloride (247259-31-0,957471-98-6)

Guidance literature:

With hydrogen; platinum on activated charcoal; In methanol; at 20 ℃; for 15h; under 2068.59 Torr;

Reference yield:

3-pyridineacetic acid hydrochloride (6419-36-9) → methyl 3-piperidylacetate hydrochloride (247259-31-0,957471-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 24 h / 20 °C

2: 0.93 g / H₂ / Pt/C / methanol / 15 h / 20 °C / 2068.59 Torr

With thionyl chloride; hydrogen; platinum on activated charcoal; In methanol;

Reference yield: 94.0%

methyl 2-[(3S)-piperidin-3-yl]acetate hydrochloride (247259-31-0,957471-98-6) + tert-butyl 3-formylpyrrolidine-1-carboxylate (59379-02-1,191348-04-6) → tert-butyl 3-{[(3S)-3-(2-methoxy-2-oxoethyl)piperidin-1-yl]methyl}pyrrolidine-1-carboxylate

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

upstream raw materials:

methyl 3-pyridylacetate hydrochloride

3-pyridineacetic acid hydrochloride

Downstream raw materials:

(R)-3-methoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

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