1-amino-N-(cyanomethyl)cyclohexanecarboxamide

Base Information

Chemical Name:1-amino-N-(cyanomethyl)cyclohexanecarboxamide
CAS No.:225122-32-7
Molecular Formula:C9H15N3O
Molecular Weight:181.238
Hs Code.:
Mol file:225122-32-7.mol

Synonyms:homocycloleucyl glycinonitrile;1-amino-N-(cyanomethyl)cyclohexanecarboxamide;homocycloleucyl-glycine-nitrile;1-amino-N-cyanomethylcyclohexanecarboxamide;1-amino-cyclohexancarboxylic acid cyanomethyl-amide;Cyclohexanecarboxamide;1-amino-cyclohexanecarboxylic acid cyanomethyl-amide;

Suppliers and Price of 1-amino-N-(cyanomethyl)cyclohexanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-amino-N-(cyanomethyl)cyclohexanecarboxamide

Chemical Property:

Boiling Point:413.6±38.0 °C(Predicted)
PKA:14.47±0.20(Predicted)
PSA：78.91000
Density:1.115±0.06 g/cm3(Predicted)
LogP:1.37898

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-amino-N-(cyanomethyl)cyclohexanecarboxamide

There total 8 articles about 1-amino-N-(cyanomethyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 3253-43-8
Spiro<4.5>decan-2,4'-oxazolidine-2,5'-dione

: glycinonitrile sulfate

: 225122-32-7
1-amino-cyclohexanecarboxylic acid cyanomethyl amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h; Reflux;
DOI:10.1021/acs.jmedchem.5b00746

Reference yield: 72.0%

: 3253-43-8
Spiro<4.5>decan-2,4'-oxazolidine-2,5'-dione

: 151-63-3
cyanomethylamine sulfate

: 225122-32-7
1-amino-cyclohexanecarboxylic acid cyanomethyl amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 100 ℃; for 1h;
DOI:10.1002/chem.201101350

Reference yield:

: 2756-85-6
1-aminocyclohexane carboxylic acid

: 225122-32-7
1-amino-cyclohexanecarboxylic acid cyanomethyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; acetone / Inert atmosphere

2: triethylamine; HATU / N,N-dimethyl-formamide / Inert atmosphere

3: methanesulfonic acid / tetrahydrofuran / Inert atmosphere

With methanesulfonic acid; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/chem.201100113