N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide

Base Information

Chemical Name:N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide
CAS No.:937701-89-8
Molecular Formula:C₁₇H₁₃BrClFN₄O
Molecular Weight:423.672
Hs Code.:

Synonyms:N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide

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Chemical Property of N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide

Chemical Property:

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Technology Process of N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide

There total 6 articles about N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 15486-96-1
3-Bromopropionyl chloride

: 184356-51-2
4-(3'-chloro-4'-fluoroanilino)-6-aminoquinazoline

: 937701-89-8
N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2016.04.032

Reference yield:

: 611-09-6
5-nitroisatin

: 937701-89-8
N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride / water / 0.5 h / Reflux

1.2: 0.5 h / Reflux

2.1: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 0 - 70 °C

3.1: acetic acid / 3 h / Reflux

4.1: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 75 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

With tin(II) chloride dihdyrate; hydroxylamine hydrochloride; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.04.032

Reference yield:

: 49675-77-6
3-(hydroxyimino)-5-nitroindolin-2-one

: 937701-89-8
N-{4-[(3-chloro-4-fluorophenyl)amino]quinazoline-6-yl}-3-bromopropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 0 - 70 °C

2: acetic acid / 3 h / Reflux

3: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 75 °C

4: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

With tin(II) chloride dihdyrate; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.04.032