3-Furanacetic acid, .alpha.-aminotetrahydro-

Base Information

• Chemical Name: 3-Furanacetic acid, .alpha.-aminotetrahydro-
• CAS No.: 1169930-49-7
• Molecular Formula: C6H11NO3
• Molecular Weight: 145.15644
• Hs Code.: 2932190090
• Mol file: 1169930-49-7.mol

Synonyms:3-Furanacetic acid, .alpha.-aminotetrahydro-;2-AMino-2-(tetrahydrofuran-3-yl)acetic acid;alpha-Aminotetrahydro-3-furanacetic acid

Chemical Property of 3-Furanacetic acid, .alpha.-aminotetrahydro-

Chemical Property:

• PSA: 72.55000
• LogP: 0.13510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Amino-2-(tetrahydrofuran-3-yl)acetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Furanacetic acid, .alpha.-aminotetrahydro-

There total 14 articles about 3-Furanacetic acid, .alpha.-aminotetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-azido-2-((S)-tetrahydrofuran-3-yl)acetic acid (146255-31-4) → (2S,3'S)-3'-tetrahydrofuranylglycine (1169930-49-7,150331-97-8,150331-99-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; for 24h;

DOI:10.1021/jm00068a006

Reference yield:

2(S)-azido-2-(3(R)-tetrahydrofuranyl)acetic acid (146255-30-3) → (2S,3'R)-3'-tetrahydrofuranylglycine (1169930-49-7,150331-97-8,150331-99-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; for 24h;

DOI:10.1021/jm00068a006

Reference yield:

(2(S)-tetrahydrofuranyl)acetic acid (146255-26-7) → (2S,3'S)-3'-tetrahydrofuranylglycine (1169930-49-7,150331-97-8,150331-99-0)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 0.58 h / -15 - 0 °C

2: 1.) n-butyllithium / 1.) THF, hexane, - 60 deg C, 2.) THF, hexane, -78 deg C, 1 h

3: 1.) potassium bis(trimethylsilyl)amide, 2.) 2,4,6-triisopropylbenzenesulfonyl azide / 1.) THF, toluene, -78 deg C, 30 min, 2.) THF, toluene, -75 deg C, 2 min

4: aq. LiOH / tetrahydrofuran / 0.75 h / Ambient temperature

5: 270 mg / H₂ / 5percent Pd/C / ethanol; H₂O / 24 h

With lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm00068a006

upstream raw materials:

(S)-2-azido-2-((S)-tetrahydrofuran-3-yl)acetic acid

(2(S)-tetrahydrofuranyl)acetic acid

(S)-2-(Tetrahydro-furan-3-yl)-malonic acid

diethyl (3(S)-tetrahydrofuranyl)malonate

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