(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: (6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER
• CAS No.: 408365-87-7
• Molecular Formula: C₁₄H₂₀N₂O₄
• Molecular Weight: 280.324
• Hs Code.: 2933399090
• Mol file: 408365-87-7.mol

Synonyms:(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER;ethyl 2-(6-(tert-butoxycarbonyl)pyridin-2-yl)acetate;tert-Butyl 6-(2-ethoxy-2-oxoethyl)picolinate;Ethyl [6-[(tert-butoxycarbonyl)amino]-2-pyridinyl]acetate

Chemical Property of (6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER

Chemical Property:

• PSA: 77.52000
• LogP: 2.60720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

ethyl2-(6-(tert-butoxycarbonylamino)pyridin-2-yl)acetate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER

There total 4 articles about (6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(tert-butoxycarbonylamino)-6-picoline (90101-22-7) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate (408365-87-7)

Guidance literature:

2-(tert-butoxycarbonylamino)-6-picoline; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; at -78 ℃; for 0.5h;

Diethyl carbonate; In tetrahydrofuran; n-heptane; at -78 - 0 ℃; for 2.16667h;

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate (408365-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA

With lithium diisopropyl amide;

DOI:10.1016/j.bmcl.2005.03.110

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate (408365-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tert-butyl alcohol / 50 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 2.33 h / -78 - 0 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; tert-butyl alcohol;

upstream raw materials:

2-(tert-butoxycarbonylamino)-6-picoline

Diethyl carbonate

2-Amino-6-methylpyridine

di-tert-butyl dicarbonate

Downstream raw materials:

2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(2-aminomethyl-5-chloro-benzyl)-acetamide

2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(5-chloro-2-tetrazol-1-yl-benzyl)-acetamide

2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(5-chloro-2-[1,2,4]triazol-1-yl-benzyl)-acetamide

ethyl 2-(6-amino-pyridin-2-yl)acetate

Refernces

• 1、 -. "INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1)". Page/Page column 32; 39-40. . Retrieved 2010/11/30.