Ethyl 2-(6-aminopyridin-2-yl)acetate

Base Information

• Chemical Name: Ethyl 2-(6-aminopyridin-2-yl)acetate
• CAS No.: 71469-82-4
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50516747
• Wikidata: Q72472630
• Mol file: 71469-82-4.mol

Synonyms:ethyl 2-(6-aminopyridin-2-yl)acetate;71469-82-4;Ethyl (6-aminopyridin-2-yl)acetate;Ethyl (6-amino-2-pyridinyl)acetate;2-Pyridineacetic acid, 6-amino-, ethyl ester;ETHYL 2-(6-AMINO-2-PYRIDYL)ACETATE;6-AMINO-2-PYRIDINEACETIC ACID ETHYL ESTER;SCHEMBL5693092;DTXSID50516747;AJIPGVQKXQFJNX-UHFFFAOYSA-N;MFCD09757476;AKOS015891609;AB51555;CS-W019072;ethyl (6-amino-pyridin-2-yl)-acetate;ethyl 2-(2-Aminopyridin-6-yl)acetate;TS-00200;FT-0658743;EN300-2081202;A837190;3-Oxo-1-azetidinecarboxylic acid 2-propen-1-yl ester

Chemical Property of Ethyl 2-(6-aminopyridin-2-yl)acetate

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 298.663 °C at 760 mmHg
• PKA: 5.84±0.24(Predicted)
• Flash Point: 134.427 °C
• PSA: 65.21000
• Density: 1.168 g/cm³
• LogP: 1.35060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 180.089877630
• Heavy Atom Count: 13
• Complexity: 173

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(6-Aminopyridin-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=NC(=CC=C1)N

Technology Process of Ethyl 2-(6-aminopyridin-2-yl)acetate

There total 3 articles about Ethyl 2-(6-aminopyridin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate (408365-87-7) → ethyl 2-(6-amino-pyridin-2-yl)acetate (71469-82-4)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; dichloromethane; at 20 ℃; for 20h;

Reference yield:

6-[N,N-bis(trimethylsilyl)amino]-2-methylpyridine (71469-81-3) → ethyl 2-(6-amino-pyridin-2-yl)acetate (71469-82-4)

Guidance literature:

With hydrogenchloride; n-butyllithium; sodium chloride; In tetrahydrofuran; ethanol; hexane; carbon dioxide; water;

Reference yield:

→ ethyl 2-(6-amino-pyridin-2-yl)acetate (71469-82-4)

Guidance literature:

6--2-methylpyridin, 1. BuLi/CO2, 2. HCl/A.;

upstream raw materials:

ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate

6-[N,N-bis(trimethylsilyl)amino]-2-methylpyridine

Downstream raw materials:

ethyl [6-(3-chloro-2-methylbenzosulfonylamino)pyridin-2-yl]acetate

2-(6-amino-pyridin-2-yl)ethanol