7-IODO-1H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 7-IODO-1H-QUINAZOLIN-4-ONE
• CAS No.: 202197-77-1
• Molecular Formula: C8H5IN2O
• Molecular Weight: 272.04
• Mol file: 202197-77-1.mol

Synonyms:7-IODO-1H-QUINAZOLIN-4-ONE;7-Iodoquinazolin-4(3H)-one;7-IODO-4(3H)-QUINAZOLINONE;7-Iodoquinazolin-4-one

Chemical Property of 7-IODO-1H-QUINAZOLIN-4-ONE

Chemical Property:

• Boiling Point: 377.4±44.0 °C(Predicted)
• PKA: 0.56±0.20(Predicted)
• PSA: 45.75000
• Density: 2.11±0.1 g/cm3(Predicted)
• LogP: 1.52770

Purity/Quality:

97% ^*data from raw suppliers

7-Iodo-3,4-dihydroquinazolin-4-one 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-IODO-1H-QUINAZOLIN-4-ONE

There total 5 articles about 7-IODO-1H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-aminoquinazolin-4-one (90004-09-4) → 7-iodo-1H-quinazolin-4-one (202197-77-1)

Guidance literature:

7-aminoquinazolin-4-one; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.416667h;

With potassium iodide; In water; at 0 - 20 ℃; for 3h;

Reference yield:

2-amino-4-iodobenzoic acid (20776-54-9) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4-hydroxy-7-iodoquinazoline (202197-77-1)

Guidance literature:

at 190 ℃; for 2h;

Reference yield:

4-iodo-2-nitrotoluene (41252-97-5) → 4-hydroxy-7-iodoquinazoline (202197-77-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water; potassium permanganate / tert-butyl alcohol / 80 °C

2: tin(II) chloride dihdyrate / ethyl acetate / 20 °C

3: 2-methoxy-ethanol / 130 °C / Inert atmosphere

With potassium permanganate; tin(II) chloride dihdyrate; water; sodium hydroxide; In 2-methoxy-ethanol; ethyl acetate; tert-butyl alcohol;

upstream raw materials:

2-amino-4-iodobenzoic acid

formamide

4-iodo-2-nitrotoluene

4-iodo-2-nitro benzoic acid

Downstream raw materials:

4-chloro-7-iodoquinazoline

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