2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL

Base Information

• Chemical Name: 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL
• CAS No.: 16175-67-0
• Molecular Formula: C10H11N3O3
• Molecular Weight: 221.21
• Hs Code.: 2933990090
• Mol file: 16175-67-0.mol

Synonyms:2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL;2-Amino-6,7-dimethoxy-4(1H)-quinazolinone

Chemical Property of 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL

Chemical Property:

• Boiling Point: 420.9±55.0 °C(Predicted)
• PKA: 3.00±0.20(Predicted)
• PSA: 90.23000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: 1.10370
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-6,7-dimethoxyquinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL

There total 5 articles about 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6,7-dimethoxy-1H-benzo[d][1,3]oxazine-2,4-dione (20197-92-6) + S-methylthiouronium iodide (4338-95-8) → 2-amino-6,7-dimethoxy-4(1H)-quinazolinone (16175-67-0)

Guidance literature:

With sodium carbonate; In water; acetonitrile; for 1.25h; Heating;

DOI:10.1021/jm00348a018

Reference yield: 79.0%

CYANAMID (420-04-2) + methyl 2-amino-4,5-dimethoxybenzoate (26759-46-6) → 2-amino-6,7-dimethoxyquinolizin-4(3H)-one (16175-67-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 80 ℃; for 7.5h;

DOI:10.1021/jm9503613

Reference yield:

2-(ethoxycarbonylamino)-4,5-dimethoxybenzoic acid (21560-74-7) → 2-amino-6,7-dimethoxy-4(1H)-quinazolinone (16175-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: PBr₃ / diethyl ether / 45 h / Heating

2: 84 percent / Na₂CO₃ / acetonitrile; H₂O / 1.25 h / Heating

With phosphorus tribromide; sodium carbonate; In diethyl ether; water; acetonitrile;

DOI:10.1021/jm00348a018

upstream raw materials:

CYANAMID

methyl 2-amino-4,5-dimethoxybenzoate

6,7-dimethoxy-1H-benzo[d][1,3]oxazine-2,4-dione

S-methylthiouronium iodide

Downstream raw materials:

2-amino-4-chloro-6,7-dimethoxyquinazoline

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