ethyl 2-(2-acetyl-4-fluorophenoxy)acetate

Base Information

• Chemical Name: ethyl 2-(2-acetyl-4-fluorophenoxy)acetate
• CAS No.: 34849-57-5
• Molecular Formula: C12H13FO4
• Molecular Weight: 240.231
• Mol file: 34849-57-5.mol

Synonyms:ethyl (2-acetyl-4-fluorophenoxy)-acetate;(2-acetyl-4-fluorophenoxy)acetic acid ethyl ester;

Chemical Property of ethyl 2-(2-acetyl-4-fluorophenoxy)acetate

Chemical Property:

• Melting Point: 40-42 °C(Solv: acetone (67-64-1))
• Boiling Point: 335.3±27.0 °C(Predicted)
• PSA: 52.60000
• Density: 1.188±0.06 g/cm3(Predicted)
• LogP: 1.97020

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 2-(2-acetyl-4-fluorophenoxy)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-acetyl-4-fluorophenoxy)acetate

There total 4 articles about ethyl 2-(2-acetyl-4-fluorophenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one (394-32-1) + chloroacetic acid ethyl ester (105-39-5) → (2-acetyl-4-fluorophenoxy)acetic acid ethyl ester (34849-57-5)

Guidance literature:

With potassium carbonate; In acetone; for 16h; Reflux; Inert atmosphere;

DOI:10.1021/jm800532x

Reference yield: 99.0%

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one (394-32-1) + ethyl iodoacetae (623-48-3) → (2-acetyl-4-fluorophenoxy)acetic acid ethyl ester (34849-57-5)

Guidance literature:

With potassium carbonate; In water; acetone;

Reference yield:

4-Fluorophenol (371-41-5) → (2-acetyl-4-fluorophenoxy)acetic acid ethyl ester (34849-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 40 °C

1.2: AlCl₃ / toluene / 80 °C

2.1: K₂CO₃ / dimethylformamide / 90 °C

With potassium carbonate; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm061428x

upstream raw materials:

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one

ethyl iodoacetae

4-Fluorophenol

chloroacetic acid ethyl ester

Downstream raw materials:

2-(2-acetyl-4-fluorophenoxy)acetic acid

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